Mulberry leaf extract reduces the glycemic indexes of four common dietary carbohydrates

Wang, Ruihua; Li, Yanfen; Mu, Wei; Li, Ziqiang; Sun, Jiao; Wang, Baohe; Zhong, Zhong; Luo, Xiaomei; Xie, Chen; Huang, Yühong

doi:10.1097/md.0000000000011996

Cited by 28 publications

(35 citation statements)

References 39 publications

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“…A number of different plant extracts have been shown to reduce postprandial glycemia or GI of common carbohydrates and carbohydrate-rich foods. Wang et al reported that consumption of mulberry leaf extracts reduced the overall glycemic response, peak glucose concentrations at 30 min, and GI of glucose by 8.2% [25]. In our study, supplementation with FFE reduced GI to a greater extent (13%–25%) compared to mulberry leaf extracts.…”

Section: Discussionsupporting

confidence: 45%

Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults

Atkinson

Villar²,

Mulà³

et al. 2019

Nutrients

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Abscisic acid (ABA) can improve glucose homeostasis and reduce inflammation in mammals by activating lanthionine synthetase C-like 2 (LANCL2). This study examined the effects of two fig fruit extracts (FFEs), each administered at two different ABA doses, on glycemic index (GI) and insulinemic index (II) to a standard glucose drink. In a randomized, double-blind crossover study, 10 healthy adults consumed 4 test beverages containing FFE with postprandial glucose and insulin assessed at regular intervals over 2 h to determine GI and II responses. Test beverages containing 200 mg FFE-50× and 1200 mg FFE-10× significantly reduced GI values by −25% (P = 0.001) and −24% (P = 0.002), respectively. Two lower doses of FFE also reduced GI values compared with the reference drink (by approximately −14%), but the differences did not reach statistical significance. Addition of FFE to the glucose solution significantly reduced II values at all dosages and displayed a clear dose-response reduction: FFE-50× at 100 mg and 200 mg (−14% (P < 0.05) and −24% (P = 0.01), respectively) and FFE-10× at 600 mg and 1200 mg (−16% (P < 0.05) and −24% (P = 0.01), respectively). FFE supplementation is a promising nutritional intervention for the management of acute postprandial glucose and insulin homeostasis, and it is a possible adjunctive treatment for glycemic management of chronic metabolic disorders such as prediabetes and type 2 diabetes mellitus.

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Section: Discussionsupporting

confidence: 45%

Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults

Atkinson

Villar²,

Mulà³

et al. 2019

Nutrients

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“…Considerable human studies have further elucidated the hypoglycemic effects of mulberry leaf extract in healthy participants, with fewer studies on prediabetes and T2DM [71][72][73]129,[131][132][133][134][135][136][137][138][139]. Liu and colleagues (2020) investigated the acute hypoglycemic effects of an extract mixture of mulberry leaf and white kidney bean in participants with IFG [74].…”

Section: White Mulberry Leafmentioning

confidence: 99%

A Narrative Review of Human Clinical Trials on the Impact of Phenolic-Rich Plant Extracts on Prediabetes and Its Subgroups

et al. 2021

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Phenolic-rich plant extracts have been demonstrated to improve glycemic control in individuals with prediabetes. However, there is increasing evidence that people with prediabetes are not a homogeneous group but exhibit different glycemic profiles leading to the existence of prediabetes subgroups. Prediabetes subgroups have been identified as: isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT), and combined impaired fasting glucose and glucose intolerance (IFG/IGT). The present review investigates human clinical trials examining the hypoglycemic potential of phenolic-rich plant extracts in prediabetes and prediabetes subgroups. Artemisia princeps Pampanini, soy (Glycine max (L.) Merrill) leaf and Citrus junos Tanaka peel have been demonstrated to improve fasting glycemia and thus may be more useful for individuals with IFG with increasing hepatic insulin resistance. In contrast, white mulberry (Morus alba Linn.) leaf, persimmon (Diospyros kaki) leaf and Acacia. Mearnsii bark were shown to improve postprandial glycemia and hence may be preferably beneficial for individuals with IGT with increasing muscle insulin resistance. Elaeis guineensis leaf was observed to improve both fasting and postprandial glycemic measures depending on the dose. Current evidence remains scarce regarding the impact of the plant extracts on glycemic control in prediabetes subgroups and therefore warrants further study.

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“…[27] Penggunaan DNJ sebagai antiobesitas dan antihiperglikemik diketahui memiliki efek samping yang lebih sedikit dibandingkan dengan acarbose, obat anti-diabetik yang juga zat penghambat enzim α-glukosidase yang telah disarankan dalam pedoman di banyak negara yang memiliki efek samping pada pencernaan seperti diare dan perut kembung. [28] Beberapa studi menunjukkan DNJ tidak memiliki potensi toksiksitas maupun efek mutagenik yang merugikan bila dikonsumsi dalam jangka panjang. [29] Iminosugar DNJ sudah digunakan dan memiliki tingkat keamanan dan tolerabilitas dalam pengobatan penyakit Gaucher yang diakibatkan lysosomal storage disorder maupun non-insulin-dependent diabetes.…”

Section: Bahasan Patogenesis Infeksi Virus Dengueunclassified

Iminosugar 1-Deoxynojirimycin (DNJ) sebagai Antiviral Infeksi Virus Dengue

Adnan

2020

kesdok

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Abstract— Dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) caused by the DENV virus are among the global problems regarding mosquito-borne viral infections. The DENV virus is transmitted through Aedes aegypti causing clinical manifestations that can cause critical illness for patients. The need for effective antiviral therapy is needed to treat DENV virus infections. 1-Deoxynojirimycin (DNJ), one of the many imino sugars found in mulberry leaves and several strains of bacteria, has potential as an antiviral against DENV virus infection. The antiviral activity of DNJ works as an inhibitor of the α-glucosidase enzyme which is important in virus secretion so that it affects the infection rate. DNJ also has the effect of boosting the immune system to initiate an immune response to a viral infection. Further research is needed to develop DNJ as an effective antiviral DENV in the future. Keywords: antiviral, dengue, iminosugar, therapy Abstrak— Dengue fever (DF), dengue hemorraghic fever (DHF), dan dengue shock syndrome (DSS) yang disebabkan oleh virus DENV merupakan salah satu permasalahan global mengenai infeksi virus. Virus DENV ditularkan melalui Aedes aegypti menyebabkan manifestasi klinis yang dapat menimbulkan kesakiatn kritis bagi pasien. kebutuhan terapi antiviral yang efektif diperlukan untuk mengobati infeksi virus DENV. 1-Deoxynojirimycin (DNJ), salah satu iminosugar yang banyak terdapat pada daun mulberry dan beberapa strain bakteri, memiliki potensi sebagai antiviral terhadap infeksi virus DENV. Aktivitas antiviral DNJ bekerja sebagai penghambat enzim α-glukosidase yang penting dalam sekresi virus sehingga mempengaruhi tingkat infeksi. DNJ juga memiliki efek meningkatkan sistem imun untuk menginisiasi respon imun terhadap infeksi virus. Penelitian lebih lanjut diperlukan untuk mengembangkan DNJ sebagai antiviral DENV yang efektif di masa depan. Kata kunci: antiviral, dengue, iminosugar, therapy

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Mulberry leaf extract reduces the glycemic indexes of four common dietary carbohydrates

Abstract: Supplemental Digital Content is available in the text

Cited by 28 publications

References 39 publications

Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults

Abscisic Acid Standardized Fig (Ficus carica) Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults

A Narrative Review of Human Clinical Trials on the Impact of Phenolic-Rich Plant Extracts on Prediabetes and Its Subgroups

Iminosugar 1-Deoxynojirimycin (DNJ) sebagai Antiviral Infeksi Virus Dengue

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