Abstract. Research and design in novel branches of technology usually require experts with different skills to cooperate on the same project. Participation of external experts is crucial for the best possible results of any significant experimentations and research. Successive iterations in these tasks need flexible validation. An ontology-based Multi-Agent System augmented with Web engineering is proposed for validation of hybrid control of biotechnological plant. For acquiring knowledge through Web, the proposed system carries out reduction, selection and validation of data and of its structures and then reconfiguration of multi agent hybrid control system.