Multi- and transgenerational disruption of maternal behavior and female puberty by Endocrine Disrupting Chemical (EDC) mixture exposure

Rodriguez, David Lopez; Aylwin, Carlos F.; Delli, Virginia; Sevrin, Elena; Campanile, Marzia; Martin, Marion; Franssen, Delphine; Gérard, Arlette; Blacher, Silvia; Tirelli, Ezio; Noël, Agnès; Lomniczi, Alejandro; Parent, Anne-Simone

doi:10.1101/2020.06.26.172965

Cited by 3 publications

(2 citation statements)

References 60 publications

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“…By DNA methylation, DNA methyltransferases add a methyl group to the cytosine base, and methylation is usually associated with the repression of transcription. Histone modification involves altering the chromatin structure; it also takes a part in the regulation of gene expression [ 36 ]. Lastly, noncoding RNAs are involved in chromatin function and can modulate gene expression with gene silencing.…”

Section: Brief Properties Of Edcsmentioning

confidence: 99%

Endocrine-Disrupting Chemicals and Disease Endpoints

Ahn

Jeung

2023

IJMS

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Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, and have been shown to interfere with physiological systems, especially by disrupting the hormone balance. During the last few decades, EDCs have been shown to affect reproductive, neurological, and metabolic development and function and even stimulate tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals have endocrine-disrupting properties, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates. These compounds have gradually been elucidated as risk factors for many diseases, such as reproductive, neural, and metabolic diseases and cancers. Endocrine disruption has been spread to wildlife and species that are connected to the food chains. Dietary uptake represents an important source of EDC exposure. Although EDCs represent a significant public health concern, the relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and the disease endpoints associated with endocrine disruption for a better understanding of the relationship between EDCs-disease and elucidates the development of new prevention/treatment opportunities and screening methods.

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Section: Brief Properties Of Edcsmentioning

confidence: 99%

Endocrine-Disrupting Chemicals and Disease Endpoints

Ahn

Jeung

2023

IJMS

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“…López-Rodríguez et al. ( 2021 ) provide two important examples of how neural and endocrine toxicity can be expressed across generations, one persistent and one emergent.…”

mentioning

confidence: 99%

Invited Perspective: Does Developmental Adaptation Pose Risks with Changing Toxicant Exposures?

Levin

2021

Environ Health Perspect

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Two Hits of EDCs Three Generations Apart: Evaluating Multigenerational Anxiety-Like Behavioral Phenotypes in Female Rats Exposed to Aroclor 1221 and Vinclozolin

Hilz,

Gillette,

Thompson

et al. 2024

Environ Health Perspect

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Background: Endocrine-disrupting chemicals (EDCs) are exogenous chemical compounds that interfere with the normal function of the endocrine system and are linked to direct and inherited adverse effects in both humans and wildlife. Legacy EDCs such as polychlorinated biphenyls (PCBs) are no longer used yet remain detectable in biological specimens around the world; concurrently, we are exposed to newer EDCs like the fungicide vinclozolin (VIN). This combination of individuals’ direct environmental chemical exposures and any heritable changes caused by their ancestors’ chemical exposures leads to a layered pattern of both direct and ancestrally inherited exposures that might have cumulative effects over generations. Objectives: We assessed consequences of both direct and ancestral exposure to EDCs over six generations, examining anxiety-like behaviors in maternal and paternal lines of female rats. We used the “two hits, three generations apart” multigenerational exposure model to explore how two distinct EDCs—the weakly estrogenic PCB mixture Aroclor 1221 (A1221) and the antiandrogenic VIN—interact on behavior across generations. We also explored serum hormones as a potential mechanism. Methods: Rats were prenatally exposed to A1221, VIN, or vehicle (DMSO) in the F1 generation, and a second exposure (same or different) was administered to the F4 generation. Anxiety-like behavior was measured in the Open Field test, Light:Dark box, and Elevated Plus Maze in the F1, F3, F4, and F6 generations. Serum concentrations of estradiol and corticosterone were analyzed. Results: Behavioral effects were not detectable in the F1 generation but emerged and became more robust across generations. Rats with ancestral VIN exposure demonstrated less anxiety-like behavior in the F3 paternal line in comparison with controls. Rats exposed to ancestral then prenatal A1221/VIN and VIN/A1221 had more anxiety-like behavior in the F4 maternal line, and those with two ancestral hits of VIN/VIN had more anxiety in the F6 paternal line, in comparison with controls. Discussion: Our findings suggest that anxiety-like behavioral phenotypes can manifest in rats following germline exposure to EDCs and that subsequent exposures across generations can intensify these effects in a lineage-dependent manner. https://doi.org/10.1289/EHP15621

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Multi- and transgenerational disruption of maternal behavior and female puberty by Endocrine Disrupting Chemical (EDC) mixture exposure

Cited by 3 publications

References 60 publications

Endocrine-Disrupting Chemicals and Disease Endpoints

Endocrine-Disrupting Chemicals and Disease Endpoints

Invited Perspective: Does Developmental Adaptation Pose Risks with Changing Toxicant Exposures?

Two Hits of EDCs Three Generations Apart: Evaluating Multigenerational Anxiety-Like Behavioral Phenotypes in Female Rats Exposed to Aroclor 1221 and Vinclozolin

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