Multi and transgenerational epigenetic effects of di-(2-ethylhexyl) phthalate (DEHP) in liver

Wen, Yi; Rattan, Saniya; Flaws, Jodi A.; Irudayaraj, Joseph

doi:10.1016/j.taap.2020.115123

Cited by 24 publications

(8 citation statements)

References 71 publications

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“…Phthalate exposure has also been associated with an increased BMI and the diagnosis of obesity in children [ 99 ]. The effects of DEHP exposure may also increase multigenerational hepatic fibrosis risk through the alteration of regular DNA methylation patterns [ 100 ]. Microplastics are considered a source of phthalate emission in the environment, and the high hydrophobicity and surface area of plastic particles enable the adsorption and transport of phthalates into water, soil, and sediment deposition [ 101 ].…”

Section: Environmental Impact and Health Effects Of Synthetic Plastic...mentioning

confidence: 99%

Towards a Circular Economy of Plastics: An Evaluation of the Systematic Transition to a New Generation of Bioplastics

et al. 2022

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Plastics have become an essential part of the modern world thanks to their appealing physical and chemical properties as well as their low production cost. The most common type of polymers used for plastic account for 90% of the total production and are made from petroleum-based nonrenewable resources. Concerns over the sustainability of the current production model and the environmental implications of traditional plastics have fueled the demand for greener formulations and alternatives. In the last decade, new plastics manufactured from renewable sources and biological processes have emerged from research and have been established as a commercially viable solution with less adverse effects. Nevertheless, economic and legislative challenges for biobased plastics hinder their widespread implementation. This review summarizes the history of plastics over the last century, including the most relevant bioplastics and production methods, the environmental impact and mitigation of the adverse effects of conventional and emerging plastics, and the regulatory landscape that renewable and recyclable bioplastics face to reach a sustainable future.

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Section: Environmental Impact and Health Effects Of Synthetic Plastic...mentioning

confidence: 99%

Towards a Circular Economy of Plastics: An Evaluation of the Systematic Transition to a New Generation of Bioplastics

et al. 2022

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“…Maternal exposure to phthalates was reported to cause metabolic disruptions, elevate body mass index (BMI), and leptin levels in the exposed population (Ashley-Martin et al, 2014 ; Buckley et al, 2016a , b ; Maresca et al, 2016 ). Experimental studies have reported multiple mechanisms for phthalates-associated metabolic disruption, including damage and changes to hepatic metabolism (Zhang et al, 2018 ; Wen et al, 2020 ), enhanced adipose differentiation (Hunt et al, 2017 ), alteration in genes associated with β-cell developmental (Rajesh and Balasubramanian, 2015 ), and dysbiosis of gut microbiota (Fan et al, 2020 ). Altered phosphorylation of endothelial nitric oxide synthase and induction of angiotensin type 1 receptor could elevate blood pressure (Lee et al, 2016 ) and further contribute to metabolic disruption by phthalates.…”

Section: Prenatal Exposure To Edcs and Metabolic Syndromementioning

confidence: 99%

“…Phthalates might also induce miRNAs modifications to alter the cholesterol efflux in RAW 264.7 cells (Park et al, 2019b ). Maternal exposure to phthalates (DEHP) was also associated with altered DNA methylation in liver (Wen et al, 2020 ) and hypermethylation of genes (Pdx1, Pax4/6, and HNF-4α) involved in pancreatic β-cell development (Rajesh and Balasubramanian, 2015 ). All these could promote diabetes and obesity phenotype, which was closely linked with metabolic syndrome.…”

Section: Determining Common Mechanisms Associated With Exposure To Edcsmentioning

confidence: 99%

Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health

et al. 2021

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Developmental origin of health and disease postulates that the footprints of early life exposure are followed as an endowment of risk for adult diseases. Epidemiological and experimental evidence suggest that an adverse fetal environment can affect the health of offspring throughout their lifetime. Exposure to endocrine disrupting chemicals (EDCs) during fetal development can affect the hormone system homeostasis, resulting in a broad spectrum of adverse health outcomes. In the present review, we have described the effect of prenatal EDCs exposure on cardio-metabolic-renal health, using the available epidemiological and experimental evidence. We also discuss the potential mechanisms of their action, which include epigenetic changes, hormonal imprinting, loss of energy homeostasis, and metabolic perturbations. The effect of prenatal EDCs exposure on cardio-metabolic-renal health, which is a complex condition of an altered biological landscape, can be further examined in the case of other environmental stressors with a similar mode of action.

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“…These observations suggest a possible preference of DEHPinduced DNA methylation for germ cells and/or spermatogenesis-related genes. Previous studies have shown that maternal DEHP exposure induces DNA methylation not only in testis but also in other tissues such as adrenal gland and liver (Quinnies et al, 2015;Wen et al, 2020); notably, DEHP exposure resulted in a significant increase in the expression, in the liver of the offspring, of Dnmt1, a gene encoding a DNA methyltransferase. These results suggested that upregulation of Dnmt1 by DEHP plays a role in DNA hypermethylation.…”

Section: Dehp Exposurementioning

confidence: 99%

“…Di (2-ethylhexyl) phthalate (DEHP) is a plasticizer that is used in a wide range of consumer products, such as food packing, medical devices, and wallpapers. Maternal exposure to DEHP has been shown to affect spermatogenesis in male offspring (Doyle et al, 2013) as well as several other body systems over multiple generations, including the female reproductive system (Brehm et al, 2018), liver (Wen et al, 2020), and anxiety-like behavior (Quinnies et al, 2015). Concerning influences on spermatogenic cells, offspring that are exposed prenatally to DEHP show defects in spermatogenesis, decreases in sperm number, and reduction of sperm motility (Doyle et al, 2013;Prados et al, 2015;Stenz et al, 2017), and F1 sperm demonstrate altered DNA methylation and expression of the genes encoding seminal vesicle secretory protein 2 (Svs2; also known as semenogelin-1); Svs3b; Svs4; and seminal vesicle antigen (Sva), all of which are involved in sperm motility (Stenz et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Epi-mutations for spermatogenic defects by maternal exposure to Di (2-ethylhexyl) phthalate

Tando

Hiura

Takehara

et al. 2021

Preprint

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Exposure to environmental factors during fetal development may lead to epigenomic modifications in fetal germ cells, altering gene expression and promoting diseases in successive generations. In mouse, maternal exposure to Di (2-ethylhexyl) phthalate (DEHP) is known to induce defects in spermatogenesis in successive generations, but the mechanism(s) of impaired spermatogenesis are unclear. Here, we showed that maternal DEHP exposure results in DNA hypermethylation of promoters of spermatogenesis-related genes in fetal testicular germ cells in F1 mice, and hypermethylation of Hist1h2ba, Sycp1 and Taf7l, which are crucial for spermatogenesis, persisted from fetal testicular cells to adult spermatogonia, resulting in the downregulation of expression of these genes. Forced methylation of these gene promoters silenced expression of these loci in a reporter assay. Expression and methylation of those genes tended to be downregulated and increased, respectively in F2 spermatogonia following maternal DEHP exposure. These results suggested that DEHP induced hypermethylation of Hist1h2ba, Sycp1 and Taf7l in fetal germ cells results in downregulation of these genes in spermatogonia and subsequent defects in spermatogenesis, at least in the F1 generation.

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Multi and transgenerational epigenetic effects of di-(2-ethylhexyl) phthalate (DEHP) in liver

Cited by 24 publications

References 71 publications

Towards a Circular Economy of Plastics: An Evaluation of the Systematic Transition to a New Generation of Bioplastics

Towards a Circular Economy of Plastics: An Evaluation of the Systematic Transition to a New Generation of Bioplastics

Developmental Exposure to Endocrine Disrupting Chemicals and Its Impact on Cardio-Metabolic-Renal Health

Epi-mutations for spermatogenic defects by maternal exposure to Di (2-ethylhexyl) phthalate

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