Kłodzko Land is one of the most important regions of Poland in terms of tourism and health issues. Numerous tourism attractions and health resorts make the region attractive for both tourist and bathers. The goal of this paper was to evaluate the impact of weather conditions on tourism-related conditions and their changes in the multiannual period. In the analysis, the indices of heat days, the UTCI (Universal Thermal Climate Index) and CTIS (Climate Tourism Information Scheme) tools were used. The research on heat days and the UTCI indicated a significant increase in the heat-stress frequency over the last decades. Simultaneously, the number of weather types related to cold stress has considerably decreased. Such trends were noticed in the entire region, in all the considered hypsometric zones. The rising tendency was also observed for strong and very strong heat stress (UTCI > 32 °C), which negatively affects health problems. The analysis showed that the most extreme thermal and biothermal conditions, in terms of heat stress, occur under southern and eastern anticyclonic circulation. The CTIS analysis showed that favorable weather conditions for most of tourism activities are noticed in the warm half-year. The usefulness of weather conditions for tourism can vary depending on atmospheric circulation.