Multi‐arm PEG/Silica Hydrogel for Sustained Ocular Drug Delivery

Lü, Chunxin; Zahedi, Payam; Forman, Adam; Allen, Christine

doi:10.1002/jps.23777

Cited by 26 publications

(10 citation statements)

References 58 publications

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“…Tunable biodegradability can also be conferred by adding ester or urethane bonds into the polymer backbone to allow for hydrolysis [95]. PEG-based hydrogels have been used to encapsulate both hydrophilic and hydrophobic drugs, including hormones such as insulin [96] and steroids [97].…”

Section: Classifying Hydrogels Based On Polymer Typementioning

confidence: 99%

Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases

Seah

Zhao

Lin

et al. 2020

Eye

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Anti-vascular endothelial growth factors (anti-VEGF) have become the most common treatment modality for many retinal diseases. These include neovascular age-related macular degeneration (n-AMD), proliferative diabetic retinopathy (PDR) and retinal vein occlusions (RVO). However, these drugs are administered via intravitreal injections that are associated with sight-threatening complications. The most feared of these complications is endophthalmitis, a severe infection of the eye with extremely poor visual outcomes. Patients with retinal diseases typically have to undergo multiple injections before achieving the desired therapeutic effect. Each injection incurs the risk of the sight-threatening complications. As such, there has been great interest in developing sustained delivery platforms for anti-VEGF agents to the posterior segment of the eye. In recent years, there have been various strategies that have been conceptualised. These include non-biodegradable implants, nano-formulations and hydrogels. In this review, the barriers of drug delivery to the posterior segment of the eye will be explained. The characteristics of an ideal sustained delivery platform will then be discussed. Finally, the current available strategies will be analysed with the above-mentioned characteristics in mind to determine the advantages and disadvantages of each sustained drug delivery modality. Through the above, this review attempts to provide an overview of the sustained delivery platforms in their various phases of development.These authors contributed equally: Ivan Seah Yu Jun, Zhao Xin Xin 1234567890();,:1234567890();,:

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Section: Classifying Hydrogels Based On Polymer Typementioning

confidence: 99%

Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases

Seah

Zhao

Lin

et al. 2020

Eye

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“…Even though conventional polymer-based contact lenses may exhibit high bioavailability, their life span is limited [96,97]. By contrast, the characteristics of MIPs make reusable contact lenses possible, and this can reduce treatment costs.…”

Section: Ocular Route Of Administrationmentioning

confidence: 99%

Advances in Molecularly Imprinted Polymers as Drug Delivery Systems

Li¹,

Poma

2021

Molecules

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Despite the tremendous efforts made in the past decades, severe side/toxic effects and poor bioavailability still represent the main challenges that hinder the clinical translation of drug molecules. This has turned the attention of investigators towards drug delivery vehicles that provide a localized and controlled drug delivery. Molecularly imprinted polymers (MIPs) as novel and versatile drug delivery vehicles have been widely studied in recent years due to the advantages of selective recognition, enhanced drug loading, sustained release, and robustness in harsh conditions. This review highlights the design and development of strategies undertaken for MIPs used as drug delivery vehicles involving different drug delivery mechanisms, such as rate-programmed, stimuli-responsive and active targeting, published during the course of the past five years.

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“…The two main possible scenarios for ocular delivery are implantable systems or medicated contact lenses. For example, Lu et al described a PEG/silica hydrogel system capable of delivering hydrophilic and hydrophobic drugs [ 76 ]. This system was designed to be injected into the eye to create a depot for the sustained delivery of dexamethasone.…”

Section: Delivery Applicationsmentioning

confidence: 99%

“…In this work, multiarm poly(ethylene glycol) (PEG)/silica hydrogels were synthesized. The synthetic process was carried out by hydrolysis and condensation of poly(4-arm PEG silicate) using the sol-gel method [ 76 ]. Similarly, Xi et al developed an injectable thermosensitive hydrogel based on poly(trimethylene carbonate) and Pluronic F127 to deliver mitomycin C [ 77 ].…”

Section: Delivery Applicationsmentioning

confidence: 99%

Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications

Larrañeta

Stewart

Ervine

et al. 2018

JFB

225

131

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Hydrogels have been shown to be very useful in the field of drug delivery due to their high biocompatibility and ability to sustain delivery. Therefore, the tuning of their properties should be the focus of study to optimise their potential. Hydrogels have been generally limited to the delivery of hydrophilic drugs. However, as many of the new drugs coming to market are hydrophobic in nature, new approaches for integrating hydrophobic drugs into hydrogels should be developed. This article discusses the possible new ways to incorporate hydrophobic drugs within hydrogel structures that have been developed through research. This review describes hydrogel-based systems for hydrophobic compound delivery included in the literature. The section covers all the main types of hydrogels, including physical hydrogels and chemical hydrogels. Additionally, reported applications of these hydrogels are described in the subsequent sections.

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Multi‐arm PEG/Silica Hydrogel for Sustained Ocular Drug Delivery

Cited by 26 publications

References 58 publications

Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases

Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases

Advances in Molecularly Imprinted Polymers as Drug Delivery Systems

Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications

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