Multi-box mass balance model of PFOA and PFOS in different regions of San Francisco Bay

Sánchez-Soberón, Francisco; Sutton, Rebecca; Sedlak, Margaret D.; Yee, Donald; Schuhmacher, Marta; Park, June-Soo

doi:10.1016/j.chemosphere.2020.126454

Cited by 11 publications

(4 citation statements)

References 41 publications

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“…The multi-box mass balance model can be used to predict the fate of POPs in the environment and to gain an appreciation of the relative importance of various fate processes (Mackay et al, 1994). The model had been applied to perfluorooctanoic acid (PFOA) and polychlorinated biphenyls (PCBs) in bays and lakes, respectively (Mackay et al, 1994;Sanchez-Soberon et al, 2020), and could provide a new perspective on the fate interpretation of DP.…”

Section: Introductionmentioning

confidence: 99%

Source, fate and budget of Dechlorane Plus (DP) in a typical semi-closed sea, China

Zhen

Wang

et al. 2021

Environmental Pollution

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Section: Introductionmentioning

confidence: 99%

Source, fate and budget of Dechlorane Plus (DP) in a typical semi-closed sea, China

Zhen

Wang

et al. 2021

Environmental Pollution

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“…Given that

is produced in adipose tissue, an inverse association between PFOA and

in circulating serum may align with our earlier published finding that BMI was lower in girls with greater PFOA exposure. 44 Based on findings from exposure studies of other populations in these areas, 13 , 45 , 46 we infer that their mothers were also exposed to PFAS in drinking water and the girls were exposed in utero , although we do not have any direct information about maternal exposure levels of the girls in our cohort. We conclude that PFAS may delay pubertal onset through the intervening effects on BMI and reproductive hormones.…”

Section: Discussionmentioning

confidence: 99%

Exposure to Perfluoroalkyl Substances and Associations with Pubertal Onset and Serum Reproductive Hormones in a Longitudinal Study of Young Girls in Greater Cincinnati and the San Francisco Bay Area

Pinney,

Fassler,

Windham

et al. 2023

Environ Health Perspect

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Background: Per- and polyfluoroalkyl substances (PFAS), endocrine disrupting chemicals with worldwide exposure, cause changes in mammary gland development in rodents. A few human studies report delay in pubertal events with increasing perfluorooctanoic acid (PFOA) exposure, but to our knowledge none have examined reproductive hormone levels at thelarche. Methods: In a cohort of Greater Cincinnati (GC) and San Francisco Bay Area (SFBA) girls recruited at 6–8 years of age, clinical examinations were conducted annually or semiannually with sequential Tanner staging. PFAS concentrations were measured in the first serum sample of 704 girls. In 304 GC girls, estradiol ( ), estrone ( ), testosterone (T), and dihydroepiandrosterone sulfate (DHEAS) were measured in serum at four time points around puberty. Relationships between PFAS and age at thelarche, pubarche, and menarche were analyzed using survival and structural equation models. The association between PFAS and reproductive hormones was assessed using linear regression models. Results: Median PFOA serum concentrations in GC ( , ) and the SFBA ( , ) were higher than in the U.S. population. In multivariable Cox proportional hazard models [adjusted for race, body mass index (BMI)], increasing serum log-transformed PFOA was associated with a delay in pubarche [ ; 95% CI: 0.70, 0.99] and menarche ( ; 95% CI: 0.01, 0.25). Structural equation models indicated a triangular relationship between PFOA, BMI percentile, and the age at the pubertal milestone. Increased PFOA had a statistically significant direct effect of delay on all three milestones, as did BMI. Perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDeA), and 2-( -methyl-perfluorooctane sulfonamido) acetic acid (Me-PFOSA-AcOH) also were associated with later thelarche, and Me-PFOSA-AcOH also with later pubarche. PFOA was inversely associated with DHEAS ( ), ( ), and T ( ) concentrations at 6 months prior to puberty. Conclusions: PFAS may delay pubertal onset through the intervening effects on BMI and reproductive hormones. The decreases in DHEAS and associated with PFOA represent biological biomarkers of effect consistent with the delay in onset of puberty. https://doi.org/10.1289/EHP11811

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“…Ahmed et al (2020b) noted decreasing adsorption onto activated carbon as the carbon chain length increased in PFAS, although longer-chain PFAS have larger partition coefficient values than shorter-chained versions. Using numerical studies of PFOS transport within unsaturated soil, researchers have concluded that groundwater contamination could occur from decades to centuries after an initial surface spill (Mahinroosta et al 2021;Sánchez-Soberón et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Per- and Polyfluoroalkyl Substances Presence, Pathways, and Cycling through Drinking Water and Wastewater Treatment

et al. 2022

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Multi-box mass balance model of PFOA and PFOS in different regions of San Francisco Bay

Cited by 11 publications

References 41 publications

Source, fate and budget of Dechlorane Plus (DP) in a typical semi-closed sea, China

Source, fate and budget of Dechlorane Plus (DP) in a typical semi-closed sea, China

Exposure to Perfluoroalkyl Substances and Associations with Pubertal Onset and Serum Reproductive Hormones in a Longitudinal Study of Young Girls in Greater Cincinnati and the San Francisco Bay Area

Per- and Polyfluoroalkyl Substances Presence, Pathways, and Cycling through Drinking Water and Wastewater Treatment

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