Multi‐Center Clinical Comparison of Combination Anorganic Bovine‐Derived Hydroxyapatite Matrix (ABM)/Cell Binding Peptide (P‐15) and ABM in Human Periodontal Osseous Defects. 6‐Month Results

Abstract

These results suggest that the use of the P-15 synthetic cell-binding peptide combined with ABM yields better clinical results than the ABM alone in intrabony periodontal defects.

Evaluation of ABM/P-15 versus autogenous bone in an ovine lumbar interbody fusion model

“…Furthermore, the 9.0 ± 7.3% of residual ABM/P-15 revealed by histomorphometry may have continued to form new bone in vivo and added to the percentage of new bone formation, thus making the difference between the mean scores of the treatments even smaller with additional time (Table 3). The successful bone formation results achieved in this study with ABM/P-15 are consistent with results obtained in other preclinical models [14][15][16], dental models [17][18][19][20][21][22][23][24][25][26], and the pilot orthopaedic model [9].…”

“…They concluded that ABM/P-15 might have a beneficial effect in the long-term clinical management of infrabony defects. In a separate study by Yukna et al [25] they found that ABM/P-15 yielded better clinical results than ABM alone in infrabony periodontal defects, showing that P-15 is needed for optimal results in vivo. In fact, ABM/P-15 had C 90% defect fill in 3.5 times more treatment areas than ABM alone, and ABM alone had twice as many failures, as defined by minimal response to treatment.…”

“…Both studies concluded that P-15 is an appropriate bone graft substitute to create new bone. Furthermore, ABM/P-15 has been used in humans for the regeneration of bone in periodontal defects for almost 10 years [17][18][19][20][21][22][23][24][25][26].…”

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“…[19][20][21] Over the past two decades, different bioactive materials have been produced and examined experimentally to exhibit an obvious capability for endogenous regenerative activity; however, there were no considered definite standards. [22][23][24][25] …”

Ultrastructure and Analytical Features of the Sinus Floor Augmentation with Osteograph<sup>®</sup> and PepGen P-15<sup>®</sup>

“…It is used in periodontics for treatment of bone defects and for bone grafting in implant dentistry. Clinical studies regarding the use of ABM P-15 in human infrabony defects in extraction sockets, in human periodontal osseous defects and in animal periodontal regeneration have been already published [14][15][16][17][18][19][20][21][22][23]. In pre-implant surgery ABM P-15 has also been used with cortical autologous bone in ridge augmentation [24,25].…”