Multi-centre classification of functional neurological disorders based on resting-state functional connectivity

Agreement and disagreement in pediatric functional neurological symptom disorders: Comparing patient reported outcome measures (PROMs) and clinician assessments

“…Functional neurological symptom disorders in children and adolescents have received growing attention in recent years because of their significant impact on the quality of life of children and their families [55] . These disorders manifest as a diverse range of neurological symptoms, including movement and pain disturbances [1] . The burden of FNSD extends beyond physical health, as it can also affect scholastic performance [43] , [56] .…”

“…Functional Neurological Symptom Disorder (FNSD) is a condition in which patients experience neurological symptoms, such as movement and pain disorders, without any known underlying neurological conditions [1] . Manifestations of movement disorders include weakness or paralysis; abnormal movements such as tremors, dystonia, myoclonus, gait disturbances, and dysphagia; and speech impairments such as dysphonia or slurred speech [2] .…”

Non-invasive neuromodulation of the right temporoparietal junction using theta-burst stimulation in functional neurological disorder

“…8 Of particular interest is the right temporoparietal junction (rTPJ) as a multisensory association cortex that evaluates the concordance between the intention of a movement and the sensory feedback resulting from the executed movement. 9 In FND, abnormal activity and functional connectivity (FC) of the rTPJ have been found in resting-state imaging [10][11][12][13] but also in task-based functional MRI (fMRI) during involuntary or externally generated movements 3 4 and during recall of traumatic events. 14 Due to conflicting findings of hypoactivation or hyperactivation, deciphering the contribution of this region to FND pathophysiology remains challenging.…”

Interoceptive disruption in functional neurological disorder: a multimodal brain imaging study

“…In FND, cingulo-insular neuroimaging profiles have correlated with symptom severity (Diez et al, 2019; Li et al, 2014; Perez et al, 2021) and indices of disease risk (Maurer et al, 2016). A recent multicenter study identified cingulo-insular, inferior parietal lobule, primary sensorimotor, and hippocampal resting-state functional connectivity patterns as the most discriminant features distinguishing FND vs. HCs in a machine learning classification (Weber et al, 2022). In task-related emotion processing and motor fMRI studies in FND cohorts, altered visceromotor activations (i.e., insula, cingulate gyrus, ventromedial prefrontal cortex (vmPFC)) were also reported (Aybek et al, 2015; Goodman et al, 2022; Voon et al, 2011).…”