Multi‐Component Approach for Synthesis of Quinolinyl‐1,4‐dihydropyridines, Evaluation of Cytotoxicity against MCF7 and Molecular Docking Studies

Selvendran, Suresh; Das, Souvik; Waidha, Kamaran; Maity, Ritwik; Basu, Biswarup; Saravanakumar, R.

doi:10.1002/slct.202002612

Cited by 5 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[100] In 2020, Basu and Rajendran et al applied a simple one-pot procedure to achieve highly functionalized quinoline-substi- ). [101] Among all the compounds evaluated for cytotoxic effect against MCF7, three products were found as a valuable scaffolds to develop anticancer drugs.…”

Section: Pyridines and Tetrahydropyridinesmentioning

confidence: 99%

“…applied a simple one‐pot procedure to achieve highly functionalized quinoline‐substituted 1,4‐dihydropyridines 42 from arylformylacetonitriles 1 , tetrazolo[1,5‐ a ]quinoline‐4‐carbaldehyde 40 , and β‐enamines 41 (Scheme 6). [101] Among all the compounds evaluated for cytotoxic effect against MCF7, three products were found as a valuable scaffolds to develop anticancer drugs.…”

Section: Mcrs Of Arylformylacetonitriles To Synthesize Monocyclic Het...mentioning

confidence: 99%

See 1 more Smart Citation

Arylformylacetonitriles in Multicomponent Reactions Leading to Heterocycles

Yuan

2022

Eur J Org Chem

View full text Add to dashboard Cite

Arylformylacetonitriles are versatile and attractive synthons in organic synthesis owing to their high reactivity. Among the numerous transformations involving arylformylacetonitriles, multicomponent reactions (MCRs) offer straightforward and effective routes to assemble the reactants into a wide range of five-and six-membered heterocyclic systems including pyrrole, pyrazole, triazole, furan, pyridine, pyrimidine, and pyran. This review collects the recent advances and applications of arylformylacetonitriles in MCRs for the synthesis of monocyclic or polycyclic heterocycles published in the literature since 2001.

show abstract

Section: Pyridines and Tetrahydropyridinesmentioning

confidence: 99%

Section: Mcrs Of Arylformylacetonitriles To Synthesize Monocyclic Het...mentioning

confidence: 99%

Arylformylacetonitriles in Multicomponent Reactions Leading to Heterocycles

Yuan

2022

Eur J Org Chem

View full text Add to dashboard Cite

show abstract

“…In this study, a multiple target approach was utilized as it is desirable to consider such targets associated with infection or diseases [29,30]. The molecular docking approach is also used for the prediction of targets against synthesized compounds, mi-rna or peptide based target inhibitors and also used for drug repurposing [30,31,32,33]. We have designed annomontine based derivatives and performed molecular docking analysis against multiple targets of SARS-CoV-2 such as MPRO, ACE2, spike protein, etc.…”

Section: Designed Ligands and Molecular Docking Analysismentioning

confidence: 99%

Design and identification of novel annomontine analogues against SARS-CoV-2: An in-silico approach

Waidha¹,

Saxena²,

Kumar³

et al. 2021

Heliyon

Self Cite

View full text Add to dashboard Cite

Aims: COVID-19 has currently emerged as the major global pandemic affecting the lives of people across the globe. It broke out from Wuhan Province of China, first reported to WHO on 31 st December 2019 as "Pneumonia of unknown cause". Over time more people were infected with this virus, and the only tactic to ensure safety was to take precautionary measures due to the lack of any effective treatment or vaccines. As a result of unavailability of desired efficacy for previously repurposed drugs, exploring novel scaffolds against the virus has become the need of the hour. Main methods: In the present study, 23 new annomontine analogues were designed representing β-Carboline based scaffolds. A hypothesis on its role as an effective ligand was laid for target-specific binding in SARS-CoV-2. These molecules were used for molecular docking analysis against the multiple possible drug targets using the Maestro Interface. To ensure the drug safety of these molecules ADME/Tox analysis was also performed. Key findings: The molecular docking analysis of the 23 novel molecules indicated the efficiency of these derivates against COVID-19. The efficiency of molecules was computed by the summation of the docking score against each target defined as Lig E Score and compared against Hydroxycholoquine as a standard. Based on the docking score, the majority of the annomontine derivatives were found to have increased binding affinity with targets as compared to hydroxycholoquine. Significance: Due to the lack of efficiency, effectiveness, and failure of already repurposed drugs against the COVID-19, the exploration of the novel scaffold that can act as effective treatment is much needed. The current study hence emphasizes the potential of Annomontine based -β-Carboline derivatives as a potential drug candidate against COVID-19.

show abstract

Synthesis of novel 2-methyl-4-carboxyquinolines, the new by-products of the Doebner reaction

Omidkhah

Ghodsi

2021

Synthetic Communications

View full text Add to dashboard Cite

Multi‐Component Approach for Synthesis of Quinolinyl‐1,4‐dihydropyridines, Evaluation of Cytotoxicity against MCF7 and Molecular Docking Studies

Cited by 5 publications

References 27 publications

Arylformylacetonitriles in Multicomponent Reactions Leading to Heterocycles

Arylformylacetonitriles in Multicomponent Reactions Leading to Heterocycles

Design and identification of novel annomontine analogues against SARS-CoV-2: An in-silico approach

Synthesis of novel 2-methyl-4-carboxyquinolines, the new by-products of the Doebner reaction

Contact Info

Product

Resources

About