Multi-component bioactive glasses of varying fluoride content for treating dentin hypersensitivity

Lynch, E; Brauer, Delia S.; Karpukhina, Natalia; Gillam, DG; Hill, Robert G.

doi:10.1016/j.dental.2011.11.021

Cited by 88 publications

(70 citation statements)

References 41 publications

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“…Rather sodium monofluorophosphate is added to the toothpaste formulation, which creates the possibility of premature reaction of calcium and fluoride to form calcium fluoride (CaF 2 ) that may compete with or inhibit subsequent fluoroapatite formation. Recently, innovators successfully incorporated fluoride, strontium, potassium, and zinc within the glass itself to produce fluoride-containing bioactive glass toothpaste with fluoride within the glass, thus enabling the delivery of Ca [19]. Originally, bioactive glasses (BG) were added in dentifrice formulations for treating dentin hypersensitivity by forming a surface layer of hydroxycarbonate apatite on the tooth, thereby occluding exposed dentinal tubules.…”

Section: Bioactive Glass Productsmentioning

confidence: 99%

“…Originally, bioactive glasses (BG) were added in dentifrice formulations for treating dentin hypersensitivity by forming a surface layer of hydroxycarbonate apatite on the tooth, thereby occluding exposed dentinal tubules. Fluoride-containing BG, however, was developed to serve as a remineralizing additive for dentifrices by releasing therapeutically active ions, such as strontium and fluoride for caries remineralization and prevention, zinc for bactericidal properties, and potassium as a desensitizing agent [19]. Fluoride-containing bioactive glass (f-BG) is engineered to release fluoride over a 12-h period within the oral environment.…”

Section: Bioactive Glass Productsmentioning

confidence: 99%

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Remineralization Therapies for Initial Caries Lesions

Amaechi

2015

Curr Oral Health Rep

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This is a review of the latest scientific advances in technologies for effective management of initial (noncavitated) caries lesions. The increasing emphasis on preventive and minimal intervention dentistry coupled with the established higher prevalence of non-cavitated caries compared to cavitated tooth surfaces is encouraging nonsurgical management of early caries among the practicing dentists. Thus, there is need for effective treatment strategies to facilitate non-operative care of initial caries lesions (remineralization). The new strategies should either facilitate fluoride action, work better than or synergistically with fluoride to provide a fuller remineralization of the lesions. An overview of new developments shows encouraging number of scientifically sound therapies with promising potential to be efficacious. However, there is shortage of strong clinical evidence generated through randomized clinical trials to support the efficacy and effectiveness of these new technologies. Devices with high validity and accuracy to measure and monitor remineralization are also needed to enable clinical data collection to validate effectiveness of these therapies.

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Section: Bioactive Glass Productsmentioning

confidence: 99%

Section: Bioactive Glass Productsmentioning

confidence: 99%

Remineralization Therapies for Initial Caries Lesions

Amaechi

2015

Curr Oral Health Rep

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“…Since human bone and dentin are very similar in composition, it can be anticipated that a material which forms an intimate bond with the bone will also form the same with the dentin 49 . A recent in-vitro scanning electron microscope (SEM) study conducted on human dentin discs has demonstrated superior tubule occlusion properties of BG as compared to the regular fluoride containing dentifrice, both pre-and post-citric acid challenge 50 .…”

Section: Treating Dentin Hypersensitivity (Dh)mentioning

confidence: 99%

Bioactive Glasses and their Applications in Dentistry

Khalid¹,

Khurshid²,

Zafar³

et al. 2017

J Pak Dent Assoc

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ABSTRACT:Biomaterials have always been used for the replacement, repair and regeneration of dental hard tissues. As the research continues, there is a significant development in the field of dental materials in terms of either developing new materials or improving the performance of the existing materials. Contrary to the development of bioinert materials, the recent hard tissue research has witnessed the development and subsequent applications of bioactive materials, a hallmark of which is the development of bioactive glass. Originally discovered in 1969, bioactive glasses have provided a reliable alternative to inert implant materials by virtue of their ability to form a stable bond with host tissues and induce subsequent remineralization especially of the dental hard tissues. This article comprehensively reviews the early development, chronological applications and mechanism of action of bioactive glasses in general and briefly encompasses their applications in clinical dentistry.

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“…Amorphous structures are thermodynamically less stable than the corresponding crystalline one, and therefore can be more susceptible to water attack and dissolution. The resulting release of fluoride ions makes these glasses of particular interest for dental applications to prevent dental caries (3,5,56) .…”

Section: Effects On Propertiesmentioning

confidence: 99%

“…It is currently also being used as the active ingredient in a remineralising dentifrice for treatment of dentine hypersensitivity (4,5) , in air abrasion applications for cutting sound and carious enamel and dentine (6) and for removing orthodontic resin adhesives (7) .…”

Section: Introductionmentioning

confidence: 99%

The role of fluoride in the nanoheterogeneity of bioactive glasses

Christie¹,

Brauer²

2017

Phys. Chem. Glasses: Eur. J. Glass Sci. Technol. B

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Fluoride--containing bioactive phospho--silicate glasses have recently attracted interest for dental applications, particularly as remineralising additives in dentifrices, and are potentially attractive for bone regeneration, particularly in patients suffering from osteoporosis. The incorporation of fluoride into phospho--silicate glasses is also attractive from a structural viewpoint: Fluoride complexes modifier ions rather than binding to the silicate network, and it thereby adds a significant ionic contribution to the average character of chemical bonds in the system. Molecular dynamics simulations have suggested that this also results in the formation of nano--heterogeneities. In this paper, we review the current knowledge on the structural role of fluoride in bioactive glasses, with a particular focus on inhomogeneities on a nano--scale.

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Multi-component bioactive glasses of varying fluoride content for treating dentin hypersensitivity

Cited by 88 publications

References 41 publications

Remineralization Therapies for Initial Caries Lesions

Remineralization Therapies for Initial Caries Lesions

Bioactive Glasses and their Applications in Dentistry

The role of fluoride in the nanoheterogeneity of bioactive glasses

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