Multi-Component HPLC Analysis and Antioxidant Activity Characterization of Extracts from<i>Dipsacus sativus</i>(Linn.) Honck

Yang, Bingxian; Feng, Xiao; Xu, Jing; Houxing, Lei; Zhang, Lin

doi:10.1080/10942912.2015.1052503

Cited by 4 publications

(14 citation statements)

References 21 publications

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“…(orientin). The presence of some of these compounds was also suggested by Kowalczyk et al [29] and Yang et al [30].…”

Section: Identification Of Iridoids and Phenolics In D Fullonum L Lsupporting

confidence: 58%

“…Similar to our work, other authors reported poor hydrogen-donating ability of iridoids. Iridoids exhibit high biological activity, especially anti-inflammatory, and perform other biological functions [11,30]. Their antioxidant activity is modulated by phenolic compounds, especially by high content of caffeoylquinic acids.…”

Section: Antioxidant and Antiacetylcholinesterase Activitymentioning

confidence: 99%

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Roots and Leaf Extracts of Dipsacus fullonum L. and Their Biological Activities

Oszmiański

Juszczyk

Nowicka

2020

Plants

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The aim of the study was to identify and evaluate the content of iridoids and phenolic compounds in the leaves and roots of Dipsacus fullonum L. They were identified and quantified by UPLC-PDA-MS/MS. Five iridoid compounds (loganic acid, loganin, sweroside, cantleyoside, and sylvestroside III) were identified in Dipsacus fullonum L. leaves and roots. Seven phenolic acids and three flavones were identified in the leaves, and seven phenolic acids were detected in the roots. The leaves contained more iridoids and phenolic compounds than the roots. We also evaluated the antimicrobial (anti-bacterial and anti-yeast), antioxidant (ORAC methods), and antiacetylcholinesterase (AChE) activities of Dipsacus fullonum L. leaves and roots. Leaf extract demonstrated the strongest antioxidant activity, but roots showed stronger antiacetylcholinesterase activity than leaves. The study also confirmed antibacterial activity of root-derived compounds against Staphylococcus aureus DSM 799 and Escherichia coli ATCC 10536.

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“…(orientin). The presence of some of these compounds was also suggested by Kowalczyk et al [29] and Yang et al [30].…”

Section: Identification Of Iridoids and Phenolics In D Fullonum L Lsupporting

confidence: 58%

Section: Antioxidant and Antiacetylcholinesterase Activitymentioning

confidence: 99%

Roots and Leaf Extracts of Dipsacus fullonum L. and Their Biological Activities

Oszmiański

Juszczyk

Nowicka

2020

Plants

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“…Liquid chromatography with various detection techniques has been widely used to determine phenolic acids. Because of the high sensitivity and selectivity, HPLC coupled to ESI-MS has received considerable attention for the determination of phenolic acids (Yang et al, 2016). Thus, we aimed to determine the phenolic contents of N. nuda subsp.…”

Section: Introductionmentioning

confidence: 99%

UHPLC-ESI-MS/MS analyses for quantification of phenolic compounds of Nepeta nuda subsp. Lydiae

Aras¹,

Bursal²,

Doğru³

2016

J App Pharm Sci

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Phenolic compounds of Nepeta nuda subsp. Lydiae leaves were identified by UHPLC-ESI-MS/MS. To the best of our knowledge, phenolic compounds in N. nuda subsp. Lydiae are reported for the first time. Chlorogenic acid, rosmarinic acid and quinic acid, were found to be the most abundant compound in the methanol extract of N. nuda subsp. Lydiae, among the twenty-seven compounds studied by LC-MS/MS. Also, smaller amounts of kaempferol, p-coumaric acid, tr-caffeic acid, apigenin, luteolin and rhamnetin were identified, quantitatively. In conclusion, leaves of N. nuda subsp. Lydiae have high potential of phenolic contents that mainly attributed with biological activities.

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“…Two main classes of substances were identified: polyphenols and iridoids. The two major polyphenols were saponarin (apigenin-6-C-glucoside-7-O-glucoside, peak 6) and chlorogenic acid (peak 1), which were the most abundantly found species in previous studies of D. fullonum L. leaves [16] and D. sativus leaves [17]. The main iridoids were sylvestrosides III and IV (peak 18), and loganic acid and loganin (peaks 2 and 4, respectively).…”

Section: Resultsmentioning

confidence: 84%

“…Previously, all the known anti-Borrelia research focused on the radix-the root of the plant with minimal activity against Lyme disease [15]. It has also been demonstrated that the composition of the leaves significantly differs from that of the root [16], demonstrating good antioxidant and antimicrobial activities [16,17]. Moreover, our research group's investigations have established the in vivo effectiveness of teasel leaves extracts against several cancer strains [18].…”

Section: Introductionmentioning

confidence: 95%

Extraction and Fractionation of Bioactives from Dipsacus fullonum L. Leaves and Evaluation of Their Anti-Borrelia Activity

et al. 2022

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Lyme disease (LD) is a tick-borne bacterial disease that is caused by Borrelia burgdorferi. Although acute LD is treated with antibiotics, it can develop into relapsing chronic form caused by latent forms of B. burgdorferi. This leads to the search for phytochemicals against resistant LD. Therefore, this study aimed to evaluate the activity of Dipsacus fullonum L. leaves extract (DE) and its fractions against stationary phase B. burgdorferi in vitro. DE showed high activity against stationary phase B. burgdorferi (residual viability 19.8 ± 4.7%); however, it exhibited a noticeable cytotoxicity on NIH cells (viability 20.2 ± 5.2%). The iridoid-glycoside fraction showed a remarkable anti-Borrelia effect and reduced cytotoxicity. The iridoid-glycoside fraction was, therefore, further purified and showed to contain two main bioactives—sylvestrosides III and IV, that showed a considerable anti-Borrelia activity being the least toxic to murine fibroblast NIH/3T3 cells. Moreover, the concentration of sylvestrosides was about 15% of DE, endorsing the feasibility of purification of the compounds from D. fullonum L. leaves.

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Multi-Component HPLC Analysis and Antioxidant Activity Characterization of Extracts fromDipsacus sativus(Linn.) Honck

Cited by 4 publications

References 21 publications

Roots and Leaf Extracts of Dipsacus fullonum L. and Their Biological Activities

Roots and Leaf Extracts of Dipsacus fullonum L. and Their Biological Activities

UHPLC-ESI-MS/MS analyses for quantification of phenolic compounds of Nepeta nuda subsp. Lydiae

Extraction and Fractionation of Bioactives from Dipsacus fullonum L. Leaves and Evaluation of Their Anti-Borrelia Activity

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