Multi-component lipid emulsion vs soy-based lipid emulsion for very low birth weight preterm neonates: A pre-post comparative study

Torgalkar, Ranjit; Dave, Shruti; Shah, Jyotsna; Ostad, Nastaran; Kotsopoulos, Kirsten; Unger, Sharon; Shah, Prakesh S.

doi:10.1038/s41372-019-0425-7

Cited by 33 publications

(31 citation statements)

References 31 publications

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“…Similar results have been found by Kapoor et al in preterm infants with surgical conditions or cholestasis 33 . In a recent large‐cohort study, practice change to routine use of an MLE rather than an SLE was not associated with changes in mortality, BPD, nosocomial infection, NEC, or ROP stage ≥3, but it was associated with improved lipid tolerance and lower odds of any ROP stage, cholestasis, and osteopenia 34 …”

Section: Discussionsupporting

confidence: 84%

“…33 In a recent large-cohort study, practice change to routine use of an MLE rather than an SLE was not associated with changes in mortality, BPD, nosocomial infection, NEC, or ROP stage ≥3, but it was associated with improved lipid tolerance and lower odds of any ROP stage, cholestasis, and osteopenia. 34 Our study has some limitations. First, it would have been useful to provide volumetric measurements through brain magnetic resonance to better define the effect of different LEs on the volume of specific brain structures.…”

Section: Discussionmentioning

confidence: 89%

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Growth of Head Circumference and Body Length in Preterm Infants Receiving a Multicomponent vs a Soybean‐Based Lipid Emulsion: A Randomized Controlled Trial

Costa

Cocca

Barone

et al. 2020

J Parenter Enteral Nutr

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Background The growth of very low‐birth‐weight (VLBW) infants relies, to a large extent, on parenteral nutrition (PN) during the early weeks of life. Despite the parenteral nutrients supply, extrauterine growth restriction remains the main concern for these infants. A parenteral multicomponent lipid emulsion (MLE) might improve growth and neurological outcomes, delivering fats for brain growth that the traditional soybean‐based lipid emulsion (SLE) fails to provide. We hypothesize that the use of an MLE in PN may reduce the loss of head circumference (HC) z‐score from birth to 36 weeks’ postmenstrual age (PMA) or at discharge compared with the use of an SLE in VLBW infants. Methods Infants with BW ≤1250 g, without malformations or chromosomal abnormalities, were randomly assigned to receive an MLE or an SLE. The primary outcome was the change in HC z‐score (HC Δ z‐score) from birth to 36 weeks’ PMA or at discharge. Secondary outcomes included the change in weight and length z‐score (W Δ z‐score and L Δ z‐score) as well as incidence of late‐onset sepsis and PN‐associated cholestasis (PNAC). Results Of the 128 infants randomized, 51 infants in the MLE group and 50 infants in the SLE group were analyzed. The MLE was significantly associated with a decreased loss in HC and length z‐scores from birth to 36 weeks’ PMA or at discharge. Conclusions This is the first randomized controlled trial providing the evidence that an MLE is associated with improved HC growth in comparison with a pure SLE.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 89%

Growth of Head Circumference and Body Length in Preterm Infants Receiving a Multicomponent vs a Soybean‐Based Lipid Emulsion: A Randomized Controlled Trial

Costa

Cocca

Barone

et al. 2020

J Parenter Enteral Nutr

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“…Lam et al found that longterm exposure (>4 weeks) to MO-LE resulted in lower conjugated bilirubin than SO-LE [66]. Torgalkar et al did not see a significant reduction in cholestasis, but did see a lower odds ratio with MO-LE use [67]; however, the authors stated this may have been due to the reduced time of treatment in the MO-LE group. Interestingly, a recent study by Ferguson el al.…”

Section: Clinical Outcomes With Mixed Oil-based Lipid Emulsionsmentioning

confidence: 97%

Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates

Guthrie

Burrin

2021

Nutrients

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Total parenteral nutrition (TPN) is a life-saving intervention for infants that are unable to feed by mouth. Infants that remain on TPN for extended periods of time are at risk for the development of liver injury in the form of parenteral nutrition associated cholestasis (PNAC). Current research suggests the lipid component of TPN is a factor in the development of PNAC. Most notably, the fatty acid composition, vitamin E concentration, and presence of phytosterols are believed key mediators of lipid emulsion driven PNAC development. New emulsions comprised of fish oil and medium chain triglycerides show promise for reducing the incidence of PNAC in infants. In this review we will cover the current clinical studies on the benefit of fish oil and medium chain triglyceride containing lipid emulsions on the development of PNAC, the current constituents of lipid emulsions that may modulate the prevalence of PNAC, and potential new supplements to TPN to further reduce the incidence of PNAC.

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“…Of note, the number of "records" does not equal the number of publications because some studies investigated multiple pathophysiological mechanisms representing different "records." Four studies demonstrated that preterm infants that received fish oil-based lipid emulsions developed ROP less frequently compared to lipid emulsions without fish oil (Beken et al 2014;Torgalkar et al 2019;Gharehbaghi et al 2020;Tu et al 2020), while two studies reported no difference (Najm et al 2017;Unal et al 2018). Further three studies from one research group reported that the overall occurrence of ROP was not reduced, but the risks of laser therapy and cholestasis were lower (Pawlik, Lauterbach, and Hurkała 2011a;Pawlik, Lauterbach, and Turyk 2011b;Pawlik et al 2014).…”

Section: Effects Of Marine Resources On Retinal Disease Prevalence and Severitymentioning

confidence: 99%

The potential of marine resources for retinal diseases: a systematic review of the molecular mechanisms

Krueger

Boehme

Klettner

et al. 2021

Critical Reviews in Food Science and Nutrition

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We rely on vision more than on any other sense to obtain information about our environment. Hence, the loss or even impairment of vision profoundly affects our quality of life. Diet or food components have already demonstrated beneficial effects on the development of retinal diseases. Recently, there has been a growing interest in resources from marine animals and plants for the prevention of retinal diseases through nutrition. Especially fish intake and omega-3 fatty acids have already led to promising results, including associations with a reduced incidence of retinal diseases. However, the underlying molecular mechanisms are insufficiently explained. The aim of this review was to summarize the known mechanistic effects of marine resources on the pathophysiological processes in retinal diseases. We performed a systematic literature review following the PRISMA guidelines and identified 107 studies investigating marine resources in the context of retinal diseases. Of these, 46 studies described the underlying mechanisms including anti-inflammatory, antioxidant, antiangiogenic/vasoprotective, cytoprotective, metabolic, and retinal function effects, which we critically summarize. We further discuss perspectives on the use of marine resources for human nutrition to prevent retinal diseases with a particular focus on regulatory aspects, health claims, safety, and bioavailability.

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Multi-component lipid emulsion vs soy-based lipid emulsion for very low birth weight preterm neonates: A pre-post comparative study

Cited by 33 publications

References 31 publications

Growth of Head Circumference and Body Length in Preterm Infants Receiving a Multicomponent vs a Soybean‐Based Lipid Emulsion: A Randomized Controlled Trial

Growth of Head Circumference and Body Length in Preterm Infants Receiving a Multicomponent vs a Soybean‐Based Lipid Emulsion: A Randomized Controlled Trial

Impact of Parenteral Lipid Emulsion Components on Cholestatic Liver Disease in Neonates

The potential of marine resources for retinal diseases: a systematic review of the molecular mechanisms

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