Multi‐component reaction‐functionalized chitosan complexed with copper nanoparticles: An efficient catalyst toward A³ coupling and click reactions in water

Abstract

A novel bio‐nanocomposite nanocatalyst with highly dispersed particles is synthesized through covalent functionalization of chitosan biopolymer by the multicomponent reaction (MCR) strategy. Surface functionalization of chitosan through MCR is led to the grafting of carboxamide type ligands with a high affinity toward complexation with copper nanoparticles. The catalytic activity of the synthesized catalyst was explored in various transformations such as A3 coupling and click reactions in water. Reusability and non‐hazardous nature of the catalyst, mild reaction conditions, operational simplicity, high yielding, and using water as a solvent are the main advantages of this catalytic protocol.

Recent developments and perspectives in the copper-catalyzed multicomponent synthesis of heterocycles

“…A systematic synthetic protocol towards an important A 3 coupling as well as click reaction was reported in 2019. 29 Chitosan complexed with Cu-nanoparticles (CS-MCR/Cu 2 O) was effectively used as catalyst for this reaction without metal leaching and loss of activity. CS-MCR/Cu 2 O catalyst was prepared by covalent functionalization of chitosan biopolymer via MCR method followed by complexing the in situ formed Cu 2 O nanoparticles with biopolymeric chitosan.…”

Cu/SiO2-Pr-NH-Benz as a novel nanocatalyst for the efficient synthesis of 1,4-disubstituted triazoles and propargyl amine derivatives in an aqueous solution

“…Synthetic approach for preparation of Cu@SiO 2 -Pr-NH-Benz. click and A 3 -coupling reactions prompted us for the present study [30]. This work reports an efficient and straightforward approach for synthesizing diverse propargylamine and 1,2,3-triazole derivatives in eco-friendly condition, excellent yield and short-time reaction.…”

Synthesis of fish scale derived hydroxyapatite silica propyl bis aminoethoxy ethane cuprous complex (HASPBAEECC) as a novel hybrid nano-catalyst for highly efficient synthesis of new benzimidazole-1,2,3-triazole hybrid analogues as antifungal agents

“…However, the emergence of unwanted side products like alkyne-alkyne homocoupling adducts restricted the utilization of Cu(I) cation in its naked shape. A common solution to this problem is chelation of Cu(I) cation to Nor P-based free ligands and/or supported ligands onto the surface of diverse solids which largely leads to promotion of Cu(I) catalytic activity [15,16]. This will in turn result in preventing desorption of Cu species from the surface of the heterogeneous catalyst which improves its reusability.…”