In this work, we consider effects of the dynamical vacuum in quantum cosmology in presence of a minimum length introduced by the GUP (generalized uncertainty principle) related to the modified commutation relation $$[{\hat{X}},{\hat{P}}] := \frac{i\hbar }{ 1 - \beta {\hat{P}}^2 }$$
[
X
^
,
P
^
]
:
=
i
ħ
1
-
β
P
^
2
. We determine the wave function of the Universe $$ \psi _{qp}(\xi ,t)$$
ψ
qp
(
ξ
,
t
)
, which is solution of the modified Wheeler–DeWitt equation in the representation of the quasi-position space, in the limit where the scale factor of the Universe is small. Although $$\psi _{qp}(\xi ,t)$$
ψ
qp
(
ξ
,
t
)
is a physically acceptable state it is not a realizable state of the Universe because $$ \psi _{qp}(\xi ,t)$$
ψ
qp
(
ξ
,
t
)
has infinite norm, as in the ordinary case with no minimal length.