Multi-element analysis of trace element levels in human autopsy tissues by using inductively coupled atomic emission spectrometry technique (ICP-AES)

Rahil-Khazen, Reem; Bolann, Bjørn J.; Myking, Andreas O.; Ulvik, Rune J.

doi:10.1016/s0946-672x(02)80004-9

Cited by 134 publications

(90 citation statements)

References 21 publications

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“…Other work has shown that the liver and the spleen are the primary sites for the deposition of Co (19). In this study, we found that in the strenuous exercise group as compared to the control group, Co was depleted in the brain stem and frontal lobe.…”

Section: Discussionsupporting

confidence: 51%

“…Although we saw notable changes in Cr only in the brain stem in the strenuous exercise group, both our data and that of a previous study show that Cr is normally present at low concentrations not only in the brain stem, but also in the frontal and temporal lobes, and that there are no apparent associations among these regions (18). Similarly, another study found that Cr levels were distributed almost evenly among the brain frontal lobe and the cerebellum (19).…”

Section: Discussioncontrasting

confidence: 50%

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Acute Effects of Moderate and Strenuous Running on Trace Element Distribution in the Brain, Liver, and Spleen of Trained Rats

et al. 2013

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Objective: Trace elements such as manganese (Mn), cobalt (Co) and chromium (Cr) play key roles in metabolic reactions and are important in many physiological enzymatic processes. In this study, we aimed to investigate the acute effects of moderate and strenuous running (treadmill) exercise on the levels of Mn, Co and Cr in the brain, liver, and spleen of trained rats.Study Design: Animal experiment.Material and Methods: Twenty-one Wistar-Albino adult male rats were used in the study. Rats were grouped as control group (no mandated exercise; n=8), moderate exercise group (30 min exercise duration; n=7), and strenuous exercise group (60 min exercise duration; n=6). The levels of Mn, Co, and Cr in the frontal lobe, temporal lobe, brain stem, liver, and spleen were determined by atomic absorption spectrophotometer.Results: Cr levels in liver of rats increased in parallel to the time course of running supporting the exercise training effect on the action of insulin. Compared to the control group, the level of Co significantly decreased in the brain stem of rats in the moderate exercise group (p=0.009) and in the frontal lobe of rats in the strenuous exercise group (p=0.004). In the strenuous exercise group, an examination of the brain stem revealed that the level of Mn significantly decreased (p=0.001), and levels of Co and Cr were apparently depleted to the extent that these elements were no longer detectable. Conclusion:A notable finding is that during or after single bout strenuous exercise, levels of Co decreased in the spleen and particularly decreased in the brain stem of regularly trained rats. From this study, it can be inferred that sportsmen should aware trace element disturbances among the body parts or depletion of some trace elements after single bout of chronic strenuous running exercise.

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Section: Discussionsupporting

confidence: 51%

Section: Discussioncontrasting

confidence: 50%

Acute Effects of Moderate and Strenuous Running on Trace Element Distribution in the Brain, Liver, and Spleen of Trained Rats

et al. 2013

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“…Yapılan korelasyon analizine göre, kadmiyum ile bakır ve çinko düzeyleri arasında anlamlı korelasyon bulundu. Kadmiyum ve çinko arasındaki anlamlı korelasyon, başka çalışmalarda da karaciğer 28 ve böbrek 18,29 için bildirilmiş bir bulgudur.…”

Section: Discussionunclassified

Levels of Trace Elements and Toxic Metals in Autopsy Renal Tissue Samples

Yilmaz¹,

Aliyev²,

Kayaaltı³

et al. 2012

Turkiye Klinikleri J Med Sci

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A An na ah ht ta ar r K Ke el li im me el le er r: : Renal korteks; kadmiyum; kurşun; çinko; bakır; Türkiye A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Metals are commonly found in air, water, soil and biologic substances. Many factors are involved in the path metals' follow to reach the food chain with air, water, soil and finally plants. Many tissue studies were conducted and reported for different countries as tissue biopsies are crucial for identifying chronic exposure. A tissue study carried out this way is not available in Turkey. Thus we aimed to detect and report levels of heavy metals (cadmium and lead) and trace elements (zinc and copper) in renal cortex tissues for Turkey. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Autopsy tissue samples used in our study were obtained from a total of 114 adult autopsy cases arrived to the Council of Forensic Medicine between June-November 2007. Measurements were done with Atomic Absorption Spectrometry. Copper and zinc were detected with Flame Atomic Absorption Technique and lead and cadmium were detected with Microwave Oven Digestion Procedure. R Re es su ul lt ts s: : Cadmium levels were 20.9-312 (μg/g), lead levels were 0.037-7.49 (μg/g), copper levels were 25.6-475 (μg/g) and cupper levels were 1.54-171 (μg/g) in renal cortex tissue. Cadmium values in our country were comparable to levels in many European countries and significantly lower compared to the values reported from Japan. Renal cortex lead values of our country were similar to those of Norway and Czech Republic and significantly lower compared to the other countries, especially USA. A significant difference was not found between zinc concentrations of our study and the values reported from other countries. Copper concentrations that we found for our country were significantly higher compared to those reported for other countries. Results were analysed according to the age, gender, smoking habit and residence of the subjects. Renal cadmium values increased with age and were found significantly higher in males compared to females. Lead and cadmium values were significantly highes among individuals who smoked. C Co on nc cl lu us si io on n: : In conclusion, renal cortex Cd, Pb, Zn and Cu levels were determined for Turkey and compared with the levels in various studies in literature.

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“…The hip membrane, for example, exhibited not only zirconium dioxide and polymethylmethacrylate abrasion products but also metals originating from the heads used to join the spacer components (such as chromium, cobalt, molybdenum, and nickel). The detection of chromium and copper in the case of knee spacers can be explained by the fact that normal human tissues naturally contain chromium, copper, and manganese as essential trace elements [39]. It also is possible the abraded material originates from the original, infected prostheses.…”

Section: Discussionmentioning

confidence: 99%

“…We determined the presence of zirconium dioxide from the cement and metal particles abraded from the spacers and the elements present in the alloys: cobalt, chromium, molybdenum, manganese, and niobium. Human tissues contain minute amounts of chromium, copper, and manganese as essential trace elements [3,39]. In contrast, zirconium dioxide is not normally present in human tissue and is used in Palacos 1 R+G and Copal 1 as opaquing agents for purposes of radiographic detection [29].…”

Section: Methodsmentioning

confidence: 99%

Articulating Spacers Used in Two-stage Revision of Infected Hip and Knee Prostheses Abrade with Time

Fink

Rechtenbach

Büchner

et al. 2011

Clinical Orthopaedics &Amp; Related Research

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Background Articulating spacers used in two-stage revision surgery of infected prostheses have the potential to abrade and subsequently induce third-body wear of the new prosthesis. Questions/purposes We asked whether particulate material abraded from spacers could be detected in the synovial membrane 6 weeks after implantation when the spacers were removed for the second stage of the revision. Patients and Methods Sixteen hip spacers (cemented prosthesis stem articulating with a cement cup) and four knee spacers (customized mobile cement spacers) were explanted 6 weeks after implantation and the synovial membranes were removed at the same time. The membranes were examined by xray fluorescence spectroscopy, xray diffraction for the presence of abraded particles originating from the spacer material, and analyzed in a semiquantitative manner by inductively coupled plasma mass spectrometry. Histologic analyses also were performed.

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Multi-element analysis of trace element levels in human autopsy tissues by using inductively coupled atomic emission spectrometry technique (ICP-AES)

Cited by 134 publications

References 21 publications

Acute Effects of Moderate and Strenuous Running on Trace Element Distribution in the Brain, Liver, and Spleen of Trained Rats

Acute Effects of Moderate and Strenuous Running on Trace Element Distribution in the Brain, Liver, and Spleen of Trained Rats

Levels of Trace Elements and Toxic Metals in Autopsy Renal Tissue Samples

Articulating Spacers Used in Two-stage Revision of Infected Hip and Knee Prostheses Abrade with Time

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