Multi‐Enzyme Activity of MIL‐101 (Fe)‐Derived Cascade Nano‐Enzymes for Antitumor and Antimicrobial Therapy

Sun, Mengmeng; Wang, Liling; Zhuo, Yong; Xu, Shengyu; Liu, Hehe; Jiang, Xuemei; Lu, Zhiwei; Wang, Xianxiang; Wang, Yanying; Yue, Guizhou; Feng, Bin; Rao, Hanbing; Wu, De

doi:10.1002/smll.202309593

Cited by 7 publications

(2 citation statements)

References 76 publications

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“…Typically, nanozymes with SOD-and CAT-like activity can act as excellent antioxidants, scavenging excessive superoxide anion and hydrogen peroxide to alleviate oxidative stress in wounds. 32 At the same time, it also generates oxygen to improve ischemic hypoxia and accelerate wound healing. 33 There have been various review articles on the application of nanozymes in wound healing.…”

Section: Introductionmentioning

confidence: 99%

“…At this point, the role of antioxidant enzymes becomes particularly important. Typically, nanozymes with SOD- and CAT-like activity can act as excellent antioxidants, scavenging excessive superoxide anion and hydrogen peroxide to alleviate oxidative stress in wounds . At the same time, it also generates oxygen to improve ischemic hypoxia and accelerate wound healing …”

Section: Introductionmentioning

confidence: 99%

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Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Xiao,

Zhao,

DuBois

et al. 2024

ACS Biomater. Sci. Eng.

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Diabetic foot ulcers (DFU) are chronic, refractory wounds caused by diabetic neuropathy, vascular disease, and bacterial infection, and have become one of the most serious and persistent complications of diabetes mellitus because of their high incidence and difficulty in healing. Its malignancy results from a complex microenvironment that includes a series of unfriendly physiological states secondary to hyperglycemia, such as recurrent infections, excessive oxidative stress, persistent inflammation, and ischemia and hypoxia. However, current common clinical treatments, such as antibiotic therapy, insulin therapy, surgical debridement, and conventional wound dressings all have drawbacks, and suboptimal outcomes exacerbate the financial and physical burdens of diabetic patients. Therefore, development of new, effective and affordable treatments for DFU represents a top priority to improve the quality of life of diabetic patients. In recent years, nanozymes-based diabetic wound therapy systems have been attracting extensive interest by integrating the unique advantages of nanomaterials and natural enzymes. Compared with natural enzymes, nanozymes possess more stable catalytic activity, lower production cost and greater maneuverability. Remarkably, many nanozymes possess multienzyme activities that can cascade multiple enzymecatalyzed reactions simultaneously throughout the recovery process of DFU. Additionally, their favorable photothermal-acoustic properties can be exploited for further enhancement of the therapeutic effects. In this review we first describe the characteristic pathological microenvironment of DFU, then discuss the therapeutic mechanisms and applications of nanozymes in DFU healing, and finally, highlight the challenges and perspectives of nanozyme development for DFU treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Xiao,

Zhao,

DuBois

et al. 2024

ACS Biomater. Sci. Eng.

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Application of Drug Delivery System Based on Nanozyme Cascade Technology in Chronic Wound

Wang,

Li,

Liu

et al. 2024

Adv Healthcare Materials

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Chronic wounds are characterized by long‐term inflammation, including diabetic ulcers, traumatic ulcers, etc., which provide an optimal environment for bacterial proliferation. At present, antibiotics are the main clinical treatment method for chronic wound infections. However, the overuse of antibiotics may accelerate the emergence of drug‐resistant bacteria, which poses a significant threat to human health. Therefore, there is an urgent need to develop new therapeutic strategies for bacterial infections. Nanozyme‐based antimicrobial therapy (NABT) is an emerging antimicrobial strategy with broad‐spectrum activity and low drug resistance compared to traditional antibiotics. NABT has shown great potential as an emerging antimicrobial strategy by catalyzing the generation of reactive oxygen species (ROS) with its enzyme‐like catalytic properties, producing a powerful bactericidal effect without developing drug resistance. Nanozyme‐based cascade antimicrobial technology offers a new approach to infection control, effectively improving antimicrobial efficacy by activating cascades against bacterial cell membranes and intracellular DNA while minimizing potential side effects. However, it is worth noting that this technology is still in the early stages of research. This article comprehensively reviews wound classification, current methods for the treatment of wound infection, different types of nanozymes, the application of nanozyme cascade reaction technology in antimicrobial therapy, and future challenges and prospects.

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Iron‐MOFs for Biomedical Applications

Yu,

Lepoitevin,

Serre

2024

Adv Healthcare Materials

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Over the past two decades, iron‐based metal–organic frameworks (Fe‐MOFs) have attracted significant research interest in biomedicine due to their low toxicity, tunable degradability, substantial drug loading capacity, versatile structures, and multimodal functionalities. Despite their great potential, the transition of Fe‐MOFs–based composites from laboratory research to clinical products remains challenging. This review evaluates the key properties that distinguish Fe‐MOFs from other MOFs and highlights recent advances in synthesis routes, surface engineering, and shaping technologies. In particular, it focuses on their applications in biosensing, antimicrobial, and anticancer therapies. In addition, the review emphasizes the need to develop scalable, environmentally friendly, and cost‐effective production methods for additional Fe‐MOFs to meet the specific requirements of various biomedical applications. Despite the ability of Fe‐MOFs–based composites to combine therapies, significant hurdles still remain, including the need for a deeper understanding of their therapeutic mechanisms and potential risks of resistance and overdose. Systematically addressing these challenges could significantly enhance the prospects of Fe‐MOFs in biomedicine and potentially facilitate their integration into mainstream clinical practice.

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Multi‐Enzyme Activity of MIL‐101 (Fe)‐Derived Cascade Nano‐Enzymes for Antitumor and Antimicrobial Therapy

Cited by 7 publications

References 76 publications

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Application of Drug Delivery System Based on Nanozyme Cascade Technology in Chronic Wound

Iron‐MOFs for Biomedical Applications

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