Multi-formalism Modelling of Cardiac Tissue

Defontaine, Antoine; Hernández, Alfredo; Carrault, Guy

doi:10.1007/11494621_39

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…Within a given sub-model, 'local' variables may be defined, permitting to follow, during actual in silico simulations, any additional appropriate processes taking place within the considered subsystem. For example, a hybrid (multi-formalism) electrophysiological model of an ischaemic cardiac tissue can be constructed as a set of coupled sub-models representing healthy and ischaemic cells (Defontaine et al 2004(Defontaine et al , 2005. Healthy cells can be represented by means of a simplified (discrete) automaton model, while ischaemic cells can be represented with a detailed (continuous) model.…”

Section: Modelling and Knowledge Management Infrastructurementioning

confidence: 99%

SAPHIR: a physiome core model of body fluid homeostasis and blood pressure regulation

Thomas

Baconnier²,

Fontecave³

et al. 2008

Phil. Trans. R. Soc. A.

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We present the current state of the development of the SAPHIR project (a Systems Approach for PHysiological Integration of Renal, cardiac and respiratory function). The aim is to provide an open-source multi-resolution modelling environment that will permit, at a practical level, a plug-and-play construction of integrated systems models using lumped-parameter components at the organ/tissue level while also allowing focus on cellular-or molecular-level detailed sub-models embedded in the larger core model. Thus, an in silico exploration of gene-to-organ-to-organism scenarios will be possible, while keeping computation time manageable. As a first prototype implementation in this environment, we describe a core model of human physiology targeting the short-and long-term regulation of blood pressure, body fluids and homeostasis of the major solutes. In tandem with the development of the core models, the project involves database implementation and ontology development.

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Section: Modelling and Knowledge Management Infrastructurementioning

confidence: 99%

SAPHIR: a physiome core model of body fluid homeostasis and blood pressure regulation

Thomas

Baconnier²,

Fontecave³

et al. 2008

Phil. Trans. R. Soc. A.

Self Cite

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“…Note that within a given submodule, "local" variables may be defined, permitting to follow, during actual in silico simulations, any additional appropriate processes taking place within the considered subsystem. For example, a hybrid (multi-formalism) electrophysiological model of an ischemic cardiac tissue, can be constructed as a set of coupled sub-models representing healthy and ischemic cells [5,6]. Healthy cells can be represented by means of a simplified (discrete) automaton model, while ischemic cells can be represented with a detailed (continuous) model.…”

Section: B Modeling and Simulation Tools Database And Ontologies And Grmentioning

confidence: 99%

SAPHIR - a multi-scale, multi-resolution modeling environment targeting blood pressure regulation and fluid homeostasis

Thomas

Abdulhay

Baconnier

et al. 2007

2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Abstract-We present progress on a comprehensive, modular, interactive modeling environment centered on overall regulation of blood pressure and body fluid homeostasis. We call the project SAPHIR, for "a Systems Approach for PHysiological Integration of Renal, cardiac, and respiratory functions". The project uses state-of-the-art multi-scale simulation methods. The basic core model will give succinct input-output (reduced-dimension) descriptions of all relevant organ systems and regulatory processes, and it will be modular, multi-resolution, and extensible, in the sense that detailed submodules of any process(es) can be "plugged-in" to the basic model in order to explore, eg. system-level implications of local perturbations. The goal is to keep the basic core model compact enough to insure fast execution time (in view of eventual use in the clinic) and yet to allow elaborate detailed modules of target tissues or organs in order to focus on the problem area while maintaining the system-level regulatory compensations.

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“…As explained in [37], there are different approaches to multi-formalism modeling. One strategy exploits the fact that models of certain formalisms can be transformed into models of certain other formalisms.…”

Section: Biological Simulation Algorithm Integrationmentioning

confidence: 99%

DEVS-based dynamic simulation of deformable biological structures

Goldstein¹

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Multi-formalism Modelling of Cardiac Tissue

Cited by 4 publications

References 20 publications

SAPHIR: a physiome core model of body fluid homeostasis and blood pressure regulation

SAPHIR: a physiome core model of body fluid homeostasis and blood pressure regulation

SAPHIR - a multi-scale, multi-resolution modeling environment targeting blood pressure regulation and fluid homeostasis

DEVS-based dynamic simulation of deformable biological structures

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