As the passenger flow distribution center cooperating with various modes of transportation, the comprehensive passenger transport hub brings convenience to passengers. With the diversification of passenger travel modes, the passenger flow scale gradually increases, which brings significant challenges to the integrated passenger hub. Therefore, it is urgent to solve the problem of early warning and response to the future passenger flow to avoid congestion accidents. In this paper, the passenger flow GRNN prediction model is proposed, based on the K-means cluster algorithm, and an improved index named BWPs (Between-Within Proportion-Similarity) is proposed to improve the clustering effect of K-means so that the clustering effect of the new index is verified. In addition, the passenger flow data are studied and trained by combining with the GRNN neural network model based on parameter optimization (GA); the passenger flow prediction model is obtained. Finally, the passenger flow of Chengdu East Railway Station has been taken as an example, which is divided into 16 models, and each type of passenger flow is predicted, respectively. Compared with the traditional method, the results show that the model can predict the passenger flow with high accuracy.