Evolution of data-hungry devices has prompted the need for an exclusive communication infrastructure that can cater to the exponential increase in the need for high-speed data access. Since optical fiber links are inherently capable of supporting hightransmission data rates, fiber systems will be an integral part of the larger strategy to provide cost-effective high-speed data access to end users. This paper demonstrates the 100 × 40-Gbps dense wavelength division multiplexing (DWDM)-based 100-km-long fiber link whose performance has been analyzed using various configurations of a hybrid optical amplifier. The performance of the proposed link has been investigated using parameters like gain (dB) and bit error rate (BER). During the analysis, it has been observed that hybrid amplification, i.e., combination semiconductor optical amplifier (SOA), erbium-doped fiber amplifier (EDFA), and Raman amplifier, delivers overwhelming gain (dB) in comparison to the conventional stand-alone amplifier. Further, it has been seen that among different positional configurations of the amplifier, symmetrically positioned hybrid amplifiers achieved the gain of 18.6 dB, while the SOA link with similar configuration and parameters delivered link gain of merely −2.6 dB. In terms of BER performance, the symmetric hybrid configuration was outstanding with BER of 10 −5 , while preamplification link BER was merely 10 −3 , and post amplification being the most undesirable. The proposed link has been designed and investigated using OptiSystem TM 14.2.