Multi-laboratory simulator studies on effects of serum proteins on PTFE cup wear

Clarke, Ian C.; Chan, Frank; Essner, Aaron; Good, Victoria; Kaddick, Christian; R, Lappalainen; Michel, Laurent; McKellop, Harry A.; McGarry, William; Schroeder, David; Selenius, Mikko; Shen, M C.; Ueno, Masuo; Wang, Aiguo; Yao, Jian

doi:10.1016/s0043-1648(01)00656-1

Cited by 44 publications

(28 citation statements)

References 21 publications

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“…Fortuitously, PTFE provides an accelerated wear test with clinical validity [46]. For explanted PTFE acetabular cups, a wear factor of 37 × 10 −6 mm 3 /Nm has been calculated [47].…”

Section: Discussionmentioning

confidence: 99%

Wear tests of orthopaedic biopolymers with the biolubricant augmented by a visco-supplement

Joyce

2009

Proceedings of the Institution of Mechanical Engineers, Part J:

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The lubricant in which both natural and replacement joints must operate is synovial fluid. In vitro wear tests of such prostheses and their biomaterials generally employ a lubricant based on bovine serum, as this contains proteins that have a critical impact in reproducing clinically valid wear rates in the laboratory. However, it is also recognised that bovine serum is not identical to synovial fluid, a key difference being that synovial fluid includes hyaluronic acid but bovine serum does not. Few clinically valid wear tests employing a lubricant that includes hyaluronic acid have been undertaken, and the results have been contradictory. To try and inform these results, a series of wear tests were undertaken using a clinically validated wear screening device to investigate the influence of the addition of hyaluronic acid to the lubricant on the wear rates on two orthopaedic biopolymers. When a clinically used hyaluronic acid solution, Ostenil ® , was added to a dilute bovine serum lubricant, it was found that wear factors were not greatly changed compared with dilute bovine serum alone. Additional wear tests were undertaken with Ostenil ® added to distilled water. Here, wear was much lower but not clinically valid as transfer films were formed on the test plates.

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“…Fortuitously, PTFE provides an accelerated wear test with clinical validity [46]. For explanted PTFE acetabular cups, a wear factor of 37 × 10 −6 mm 3 /Nm has been calculated [47].…”

Section: Discussionmentioning

confidence: 99%

Wear tests of orthopaedic biopolymers with the biolubricant augmented by a visco-supplement

Joyce

2009

Proceedings of the Institution of Mechanical Engineers, Part J:

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“…The load profile was a Paul gait curve with a peak load of 3 kN, and abduction angles of 45° and 60° were used. Diluted bovine serum supplemented with EDTA and antibacterial agents was used as lubricant [21]. The serum was filtered through a 0.2 μm filter and had a total protein content of 25 mg/ml.…”

Section: Methodsmentioning

confidence: 99%

The effect of geometry and abduction angle on the stresses in cemented UHMWPE acetabular cups – finite element simulations and experimental tests

et al. 2005

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BackgroundContact pressure of UHMWPE acetabular cup has been shown to correlate with wear in total hip replacement (THR). The aim of the present study was to test the hypotheses that the cup geometry, abduction angle, thickness and clearance can modify the stresses in cemented polyethylene cups.MethodsAcetabular cups with different geometries (Link®: IP and Lubinus eccentric) were tested cyclically in a simulator at 45° and 60° abduction angles. Finite element (FE) meshes were generated and two additional designs were reconstructed to test the effects of the cup clearance and thickness. Contact pressures at cup-head and cup-cement interfaces were calculated as a function of loading force at 45°, 60° and 80° abduction angles.ResultsAt the cup-head interface, IP experienced lower contact pressures than the Lubinus eccentric at low loading forces. However, at higher loading forces, much higher contact pressures were produced on the surface of IP cup. An increase in the abduction angle increased contact pressure in the IP model, but this did not occur to any major extent with the Lubinus eccentric model. At the cup-cement interface, IP experienced lower contact pressures. Increased clearance between cup and head increased contact pressure both at cup-head and cup-cement interfaces, whereas a decreased thickness of polyethylene layer increased contact pressure only at the cup-cement interface. FE results were consistent with experimental tests and acetabular cup deformations.ConclusionFE analyses showed that geometrical design, thickness and abduction angle of the acetabular cup, as well as the clearance between the cup and head do change significantly the mechanical stresses experienced by a cemented UHMWPE acetabular cup. These factors should be taken into account in future development of THR prostheses. FE technique is a useful tool with which to address these issues.

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“…Tests on artificial hip joints have been conducted with filtrated and disinfected calf serum, and the deionized water solution with 25 vol% calf serum was suggested for use as an artificial synovia in wear tests. [22,23] Thus, our test conditions were close to the working conditions of human joints.…”

Section: Reciprocating Sliding Friction and Wear Behaviormentioning

confidence: 65%

An In Vitro Investigation of UHMWPE Modified with Cu (II) Chelate of Bissalicylaldehyde-Ethylenediamine

Wu¹,

Gao²,

Wang³

et al. 2011

Journal of Dispersion Science and Technology

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This article investigates the performance of ultra high molecular weight polyethylene (UHMWPE) modified with 15 wt% Cu (II) chelate of bissalicylaldehyde-ethylenediamine, a type of Schiff base copper complex that has antibacterium and antitumor activity, as a potential artificial hip joint material. The modified UHMWE demonstrated excellent tribological and biocompatible properties, and a higher wear resistance, a better thermal conductivity and increased deformation resistance as compared to pure UHMWPE.

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Multi-laboratory simulator studies on effects of serum proteins on PTFE cup wear

Cited by 44 publications

References 21 publications

Wear tests of orthopaedic biopolymers with the biolubricant augmented by a visco-supplement

Wear tests of orthopaedic biopolymers with the biolubricant augmented by a visco-supplement

The effect of geometry and abduction angle on the stresses in cemented UHMWPE acetabular cups – finite element simulations and experimental tests

An In Vitro Investigation of UHMWPE Modified with Cu (II) Chelate of Bissalicylaldehyde-Ethylenediamine

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