Multi-layer 3D chirality: new synthesis, AIE and computational studies

Triple-Columned and Multiple-Layered 3D Polymers: Design, Synthesis, Aggregation-Induced Emission (AIE), and Computational Study

“…Computational studies on the trimer 7 and the related pentamer ( Figure 7 ) have been performed to analyze especially the character of the electronic transitions. Based on previous investigations on similar stacked systems ( Figure 1(b) ) [ 26 ] and other stacked PAHs such as pyrene dimers [ 27 ], calculations have been performed using two different types of methods: (i) time-dependent density functional theory (TD-DFT) using the ω B97XD range-separated functional and (ii) the ab initio second-order algebraic diagrammatic construction method (ADC(2)). More details about the methods used can be found in the SI, Section 5.…”

Regio- and Diastereoselective Vicinal Aminobromination of Electron Deficient Olefins via Phosphorus-Based GAP Protocol

“…Benefiting from the present methodology and this mechanism analysis, the utilizations of GAP chemistry for aminohalogenation and diamination of a broader scope of substrates ( Chen et al, 2003b ; Chen et al, 2004 ), in search for new chirality ( Wu et al, 2019a ; Wu et al, 2019b ; Liu et al, 2020 ) and on multi-component reactions will be further conducted in our labs ( Jiang et al, 2012a ; Jiang et al, 2012b ).…”

Synthesis of Novel Triazole Incorporated Thiazolone Motifs Having Promising Antityrosinase Activity through Green Nanocatalyst CuI‐Fe3O4@SiO2 (TMS‐EDTA)

“…Some thiazolidine‐2,4‐dione derivatives ( A in Figure 1) have been reported to exhibit tyrosinase inhibitory activity (IC 50 s = 37.6–140.3 μM). [ 26 ] Furthermore, it has been found that two 2‐(2,4‐dimethoxy phenylamino)‐5 methylene‐4‐thiazolinone derivatives ( B in Figure 1) with IC 50 values of 34.1 and 52.6 μM were effective tyrosinase inhibitors. [ 25 ] Our previous study indicated that two phthalimide‐1,2,3‐trizole hybrid compounds ( C in Figure 1) showed less inhibitory activity on tyrosinase ((IC 50 s = 26.2 and 26.5 μM) than the reference drug kojic acid did.…”

“…1,2,3–Triazole and thiazolone scaffolds have shown various biological activities including; antitumors, [ 1,2 ] anti‐HIV, [ 3 ] anti‐allergy, [ 4 ] antifungal, [ 5–7 ] anti‐infection, [ 8,9 ] anticancer, [ 10 ] antiviral, [ 11–13 ] and antimicrobial properties. [ 14–22 ] Furthermore, the regioselectivity of cycloadducts is crucial [ 23–26 ] and it has been found that some 1,2,3‐triazole and thiazolone derivatives exhibited antityrosinase activity. [ 23–26 ] Tyrosinase, also known as polyphenol oxidase, is a copper‐containing enzyme abundantly distributed in nature.…”

“…[ 14–22 ] Furthermore, the regioselectivity of cycloadducts is crucial [ 23–26 ] and it has been found that some 1,2,3‐triazole and thiazolone derivatives exhibited antityrosinase activity. [ 23–26 ] Tyrosinase, also known as polyphenol oxidase, is a copper‐containing enzyme abundantly distributed in nature. This enzyme participates in the biosynthesis of melanin by catalyzing the hydroxylation of L‐tyrosine to 3,4‐dihydroxyphenylalanine, L‐DOPA (mycophenolate activity) and subsequently, oxidation of L‐DOPA to dopaquinone (diphenolase activity).…”