Multi-layered nanofibrous mucoadhesive films for buccal and sublingual administration of drug-delivery and vaccination nanoparticles - important step towards effective mucosal vaccines

Mašek, Josef; Lubasová, Daniela; Lukac, R; Turanek-Knotigova, Pavlina; Kulich, Pavel; Plocková, Jana; Mašková, Eliška; Procházka, Lubomír; Koudelka, Štěpán; Sasithorn, Nongnut; Gombos, Jozsef; Bartheldyová, Eliška; Hubatka, František; Raška, Milan; Miller, Andrew D.; Tuřánek, Jaroslav

doi:10.1016/j.jconrel.2016.07.036

Cited by 100 publications

(59 citation statements)

References 44 publications

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“…This indicated that while low molecular weight PEG (5 kDa versus 10 kDa) enhanced the mucopenetration in general, different formulation methods could lead to changed results. Recently, Mašek et al combined mucopenetration and mucoadhesion into the same delivery platform by incorporating PEG‐PLGA nanoparticles into mucoadhesive multilayered nanofibrous films with the idea to enhance the residence time of the mucopenetrating nanoparticles in close proximity to the mucus layer. Studies on pig model after sublingual or buccal administration showed the electrospun nanofibrous layers function as protective nanoparticle reservoirs for sustained delivery of nanoparticles into submucosal tissue and draining lymphatic node sites.…”

Section: Mucus Penetrationmentioning

confidence: 99%

A Polymer Chemistry Point of View on Mucoadhesion and Mucopenetration

Schattling

Taipaleenmäki

Zhang

et al. 2017

Macromolecular Bioscience

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Although oral is the preferred route of administration of pharmaceutical formulations, the long-standing challenge for medically active compounds to efficiently cross the mucus layer barrier limits its wider applicability. Efforts in nanomedicine to overcome this hurdle consider mucoadhesive and mucopenetrating drug carriers by selectively designing (macromolecular) building blocks. This review highlights and critically discusses recent strategies developed in this context including poly(ethylene glycol)-based modifications, cationic and thiolated polymers, as well as particles with high charge density, zeta-potential shifting ability, or mucolytic properties. The latest advances in ex vivo test platforms are also reviewed.

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Section: Mucus Penetrationmentioning

confidence: 99%

A Polymer Chemistry Point of View on Mucoadhesion and Mucopenetration

Schattling

Taipaleenmäki

Zhang

et al. 2017

Macromolecular Bioscience

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“…While targeting Langerhans cells has been successful in past studies, this delivery limitation hinders the use of mucoadhesive topical delivery systems to address key questions about oral mucosal immunity and the function of other DC populations residing deeper in the mucosa. An exception to this is films that deliver nanoparticles, which are able to permeate deeper in the mucosa via paracellular transport and eventually enter the lymphatics . However, a lack of control over these trafficking mechanisms still precludes their use as a tool to probe the function of specific oral DC populations.…”

Section: The Oral Mucosa Is a Promising And Underutilized Route Of Vamentioning

confidence: 99%

Microneedle‐Mediated Vaccine Delivery to the Oral Mucosa

Creighton

Woodrow

2018

Adv Healthcare Materials

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The oral mucosa is a minimally invasive and immunologically rich site that is underutilized for vaccination due to physiological and immunological barriers. To develop effective oral mucosal vaccines, key questions regarding vaccine residence time, uptake, adjuvant formulation, dose, and delivery location must be answered. However, currently available dosage forms are insufficient to address all these questions. An ideal oral mucosal vaccine delivery system would improve both residence time and epithelial permeation while enabling efficient delivery of physicochemically diverse vaccine formulations. Microneedles have demonstrated these capabilities for dermal vaccine delivery. Additionally, microneedles enable precise control over delivery properties like depth, uniformity, and dosing, making them an ideal tool to study oral mucosal vaccination. Select studies have demonstrated the feasibility of microneedle‐mediated oral mucosal vaccination, but they have only begun to explore the broad functionality of microneedles. This review describes the physiological and immunological challenges related to oral mucosal vaccine delivery and provides specific examples of how microneedles can be used to address these challenges. It summarizes and compares the few existing oral mucosal microneedle vaccine studies and offers a perspective for the future of the field.

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“…However, successful local and systemic delivery of low‐molecular weight substances with a rapid onset of pharmacological effects have been formulated which allows the drug released at a sustained rate. Thereby providing a continuous treatment for the local diseases over a prolonged time rather than low availability of drugs and short retention time on the mucosal surface due to the complicated oral environment . As well, oral transmucosal delivery, especially buccal and sublingual delivery, has progressed far beyond the use of traditional dosage forms with novel approaches .…”

Section: Selected Properties Of Biopolymersmentioning

confidence: 99%

Biopolymers and Their Composites for Drug Delivery: A Brief Review

Gopi

Amalraj²,

Sukumaran³

et al. 2018

Macromolecular Symposia

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In recent years, excipient development has become a core area of research in pharmaceutical drug delivery because it influences the formulation development and drug delivery process in various ways. Polymeric drug delivery systems have been of great interest for controlled delivery as they show the great advantage in drug delivery systems because of optimized drug loading and releasing property. Then, the side effects of synthetic polymers far exceed that it leads to some difficulties like they impose dose reduction, treatment delay, or the given therapy is not continuous. With this in mind and together with the need for a protective delivery system for drugs, natural polymeric substances such as biopolymers and their composites are the choice of research as excipient because of their low toxicity, biodegradability, stability, and renewable nature. Furthermore, they have a wide variety of structures, different physiological functions and may provide a variety of biomedical applications, owing to their distinctive properties. The present brief review explores the concept of excipient delivery and the recent advances in both the biopolymers and the methods in the pharmaceutical drug delivery systems.

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Multi-layered nanofibrous mucoadhesive films for buccal and sublingual administration of drug-delivery and vaccination nanoparticles - important step towards effective mucosal vaccines

Cited by 100 publications

References 44 publications

A Polymer Chemistry Point of View on Mucoadhesion and Mucopenetration

A Polymer Chemistry Point of View on Mucoadhesion and Mucopenetration

Microneedle‐Mediated Vaccine Delivery to the Oral Mucosa

Biopolymers and Their Composites for Drug Delivery: A Brief Review

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