The paper reviews issues of drug use in the spread of HIV infection through sexual and injection routes, interaction of drug addicts with the general population, the main psychoactive substances used by drug addicts, the practices that contribute to the transmission of HIV from a drug addict to a healthy person, the representation of drug addicts in risk groups, the course of infections among injecting drug users (IDUs), treatment of drug use and infections in IDUs. The role of drug addiction in maintaining the HIV epidemic is shown. It is observed that people involved in seafaring are in high-risk area by drug addiction as well as by spread of HIV infection. Marine regions are among the most affected.