Crimean-Congo One of the most significant vector-borne illnesses with the potential to spread to humans after a tick bite is hemorrhagic fever (CCHF). In the Middle East and Asia, the disease is very common. contaminated tick bites, manual tick removal, and contact with contaminated tissue, blood, patients, or cattle during the acute viremic phase are risk factors for this disease. Clinical signs of the illness include fever, muscle discomfort, and increasing hemorrhages. Increased levels of creatinine phosphokinase (CPK), alanine transaminase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) are detected by biochemical testing. Pro-thrombin tests result in longer clotting times, and pathogenesis is mostly associated with epithelial destruction during viral replication and secondary cytotoxic molecule secretion. Endothelial activation is brought on by these substances, which leads to function loss. Infusions of plasma or blood are used in supportive therapy to treat or manage patients. Based on the most recent research, ribavirin, an antiviral medication that effectively prevents the disease, can be used to treat community-onset heart failure. Workers in healthcare are more likely to have infections. A thorough review of the viral epidemiology, zoonotic viewpoints, and important risk factors for community-acquired pneumonia (CCHF) in several Middle Eastern and Asian nations is provided in this book chapter. The pathophysiology and preventative measures of CCHF have also been examined, along with laws and policies pertaining to public education campaigns, research, and development projects that aim to prevent and control infections and are necessary on a worldwide scale.