Multi-locus deletion mutation induced by silver nanoparticles: Role of lysosomal-autophagy dysfunction

Si, Bo; Wang, Xue; Liu, Yun; Wang, Juan; Zhou, Yemian; Nie, Yaguang; Xu, An

doi:10.1016/j.ecoenv.2023.114947

Cited by 2 publications

(1 citation statement)

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“…Similarly, silver NPs induced oxidative stress by accumulating reactive oxygen species (ROS) in bacteria and eukaryotic cells leading to alteration in cell structure, shape, fluidity, and composition of cell contents Flores-López et al 2019;El-Houseiny et al 2021). In another study it is demonstrated that when silver NPs are injected in rodent cells, they caused permanent gene mutation and denaturation of DNA strands (Si et al 2023). Similarly, gold NPs, widely used in tumor treatments, also induce oxidative stress in hepatic HeLa, HepG2, and PMBC cells, leading to cytotoxicity (Hosseini et al 2023).…”

Section: Cytotoxicity By Oxidative Stressmentioning

confidence: 99%

Cytotoxicity and genotoxicity induced by metal-based nanoparticles in humans and animals

Rukh,

Ullah,

Naqvi

et al. 2024

Lett. Anim. Biol.

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The growing interest in nanoparticles in modern research is due to their potential uses in different fields of study. Throughout human history, individuals have been exposed to environmental nanosized particles, and over the past century, these exposures have significantly risen. Through injection, ingestion, and inhalation, nanoparticles can change the material's physicochemical characteristics and improve its ability to absorb and interact with biological tissues. Nanoparticles can penetrate the cell membrane and reach up to mitochondria and nucleus, causing gene mutation and inhibiting the mitochondrial process involved in cell metabolism. The toxicity is associated with size, shape, charge, surface area, chemical composition, and other linked factors. The in vivo behavior of these nanoparticles is still a major question that needs to be resolved. The tests are performed against the new nanoparticles during the developmental process to eliminate or ameliorate identified toxic characteristics.

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