Multi‐Metallic Nanosheets Reshaping Immunosuppressive Tumor Microenvironment through Augmenting cGAS‐STING Innate Activation and Adaptive Immune Responses for Cancer Immunotherapy
Yuxuan Peng,
Shuang Liang,
Dan Liu
et al.
Abstract:The highly immunosuppressive tumor microenvironment (TME) restricts the efficient activation of immune responses. To restore the surveillance of the immune system for robust activation, vast efforts are devoted to normalizing the TME. Here, a manganese‐doped layered double hydroxide (Mn‐LDH) is developed for potent anti‐tumor immunity by reversing TME. Mn‐LDH is synthesized via a one‐step hydrothermal method. In addition to the inherent proton neutralization capacity of LDH, the introduction of manganese oxide… Show more
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