Unmanned aircraft and, particularly, RPAS (Remotely Piloted Aircraft Systems) are nowadays experiencing great growth both in the military and civil industries. This is due to the fact that removing the need to be manned has enabled the improvement of their endurance, range, and overall performance while, at the same time, reducing the risk to which human lives were exposed. In addition, RPAS can be made much smaller. This decrease of mass and size increases the variety of missions they can perform. However, the design process to manufacture such aircraft is often long and costly, which prevents small companies from undertaking it. Multidisciplinary Design Optimization (MDO) is an engineering field whose focus is to solve highly complex problems by the means of optimization techniques. It has been used in the design of commercial aircraft for a long time, but integrating the various engineering disciplines that take part in designing an RPAS within an MDO to simplify the design process is a challenge. In addition, there is an ample variety of architectures for MDO projects and, the reasons to choose a particular one, have to be discussed on a case by case basis. During the last years, distributed architectures have become widespread, given that they can take advantage of parallel computing (even with graphical platforms) and reduce computing time. Adapting the formulation of a problem to a particular vii Dissertation Overview Chapter 1: This is the introduction to the thesis. It presents the evolution of RPAS and the current state of the art both in MDO and in RPAS design methodologies. Chapter 2 introduces the Generic Parameter Penalty Architecture (GPPA): a new, flexible MDO architecture, oriented towards the solution of engineering problems that present different levels of complexity. Chapter 3 introduces the RPAS Advanced MDO Platform (RAMP). A new MDO environment aimed at the design of small RPAS. Chapters 4-7 present RAMP's main analysis models: aerodynamics, structure, economy and pricing, propulsion, and performance. Chapter 8 presents an application case of RAMP to a real-world mission. Chapter 8 does so by limiting RAMP's configuration availability to just classical. This provides the opportunity to compare its results to most commercially available RPAS, while Chapter 9 unleashes RAMP's full capabilities to also consider Blended Wing Body (BWB) and Canard configurations. Chapter 9 presents results for the various tests and hypothesis that are presented in the thesis, while Chapter 10 serves to give shape to the conclusions of the thesis and the future lines of research.