Multi-objective design optimization of bioresorbable braided stents

Carbonaro, Dario; Lucchetti, Agnese; Audenino, Alberto L.; Gries, Thomas; Vaughan, Ted J.; Chiastra, Claudio

doi:10.1016/j.cmpb.2023.107781

Cited by 10 publications

(4 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consequently, the device becomes stiffer. Similar findings have been reported in previous studies [ 37 ] and by other authors [ 48 , 49 ]. Additionally, as a consequence of the enhanced radial strength, the radial recoil also increases.…”

Section: Resultssupporting

confidence: 93%

“…The pitch angle, denoted as

and illustrated in Figure 1 a, is a critical design parameter. The extensive research highlighted its profound impact on the radial force of the stent [ 37 , 48 , 49 , 53 ]. Within this structural context, the pitch angle significantly influences the stent’s radial recoil, thus warranting thorough evaluation in simulations.…”

Section: Methodsmentioning

confidence: 99%

“…The optimization of biodegradable stents for cardiovascular applications has been carried out by several authors with the aim of evaluating the impact of geometrical features on mechanical performance [ 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ] or trying to provide optimal designs pursuing specific hemodynamic, structural and geometrical objectives [ 50 , 51 , 52 ]. Unfortunately, these thresholds are not clearly defined for a tracheobronchial device: the main problem is migration, so radial force should be the criterion for optimization.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Computational Analysis of Polymeric Biodegradable and Customizable Airway Stent Designs

Ayechu-Abendaño,

Pérez-Jiménez,

Sánchez-Matás

et al. 2024

Polymers

View full text Add to dashboard Cite

The placement of endotracheal prostheses is a procedure used to treat tracheal lesions when no other surgical options are available. Unfortunately, this technique remains controversial. Both silicon and metallic stents are used with unpredictable success rates, as they have advantages but also disadvantages. Typical side effects include restenosis due to epithelial hyperplasia, obstruction and granuloma formation. Repeat interventions are often required. Biodegradable stents are promising in the field of cardiovascular biomechanics but are not yet approved for use in the respiratory system. The aim of the present study is to summarize important information and to evaluate the role of different geometrical features for the fabrication of a new tracheo-bronchial prosthesis prototype, which should be biodegradable, adaptable to the patient’s lesion and producible by 3D printing. A parametric design and subsequent computational analysis using the finite element method is carried out. Two different stent designs are parameterized and analyzed. The biodegradable material chosen for simulations is polylactic acid. Experimental tests are conducted for assessing its mechanical properties. The role of the key design parameters on the radial force of the biodegradable prosthesis is investigated. The computational results allow us to elucidate the role of the pitch angle, the wire thickness and the number of cells or units, among other parameters, on the radial force. This work may be useful for the design of ad hoc airway stents according to the patient and type of lesion.

show abstract

Section: Resultssupporting

confidence: 93%

“…The pitch angle, denoted as

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Computational Analysis of Polymeric Biodegradable and Customizable Airway Stent Designs

Ayechu-Abendaño,

Pérez-Jiménez,

Sánchez-Matás

et al. 2024

Polymers

View full text Add to dashboard Cite

show abstract

“…However, the weaker radial support performance compared with metal stent has limited its development in PVS therapy. To enhance the radial force of biodegradable polymer stents, researchers have systematically studied the impact of structural parameters on radial force, such as the braid angle β , 24,25 constraint mode, 26 knitting needle count N , 27 the diameter of the monofilament d , 28 and the outer diameter of the stent D 29–31 . For example, as the braid angle increases, the structure becomes looser, the interaction between the monofilaments decreases, and the radial force of the stent diminishes.…”

Section: Introductionmentioning

confidence: 99%

A biodegradable polymer stent with high radial performance: Potential for treatment of portal vein stenosis

Liu,

Wang,

et al. 2024

Polymers for Advanced Techs

View full text Add to dashboard Cite

Biodegradable polymer stents have a wide application prospect in the treatment of vascular stenosis diseases. However, weak radial performance of polymer stents hinders the treatment of the diseases with high demand for radial supporting, such as portal vein stenosis. According to previous research, the constraint mode between monofilaments is a key factor that affects the radial performance of polymer braided stent. In this work, a series of Poly(l‐lactic acid) (PLLA) stents with the elastomer coating were prepared by ultrasonic spraying process to realize the constraints of monofilament cross points. The results are showed that the radial stiffness and peak force of the coated stent are significantly increased, up to 28 and 35 times higher than that of the bare stent. It is found that the cross points are constrained by the coating, which improves the constraining force between the monofilaments resulting in the increase of the radial force during the deformation process. More importantly, the mechanism of action between the radial force of the coated stent and the mechanical performance of elastic coating has been proposed, revealing a significant positive correlation between them. The radial force of the coated stent could be quantitatively regulated by the six‐arm poly(l‐lactide‐co‐ε‐caprolactone) (6SPLCL) coating cross‐linked by Hexamethylene diisocyanate (HDI) in different proportions. Finally, we build a mechanical model of stents and find that there is a consistency between the theoretical curve and the actual curve trend. This provides further research and expands the application scope for improving the radial supporting performance of the biodegradable polymer stent.

show abstract

Application of Additive Manufacturing in the Development of Polymeric Bioresorbable Cardiovascular Stents: A Review

Yasmin,

Vafadar,

Tolouei‐Rad

2024

Adv Materials Technologies

View full text Add to dashboard Cite

Polymeric vascular bioresorbable stents (BRSs) have been widely used for the treatment of coronary artery diseases. While additive manufacturing (AM) is changing the landscape of the healthcare sector by enabling the realization of patient‐specific stents with highly complex structures. There are, however, challenges associated with the use of polymeric BRS, particularly in‐stent restenosis (ISR), related to its poor mechanical properties. Therefore, the aim of this review is to provide an overview of recent advancements in the development of polymeric BRSs designed to meet both mechanical and biological requirements. First, biopolymers as well as shape memory polymers (SMPs) that are suitable for BRSs are highlighted and briefly described. Second, different types of designing structures of vascular stents in addition to introducing effective mechanical metamaterials, e.g., negative Poisson ratio (NPR) structures are addressed. Subsequently, AM methods currently being used to fabricate polymeric BRSs, are discussed and compared with conventional fabrication methods. Lastly, future directions for research are proposed in relation to existing challenges to the realization of a new generation of AM BRSs. Overall, this paper serves as a benchmark for future cardiovascular applications, especially in order to obtain clinically viable polymeric vascular stents by selecting suitable polymers, designs, and AM technologies.

show abstract

Multi-objective design optimization of bioresorbable braided stents

Cited by 10 publications

References 35 publications

Computational Analysis of Polymeric Biodegradable and Customizable Airway Stent Designs

Computational Analysis of Polymeric Biodegradable and Customizable Airway Stent Designs

A biodegradable polymer stent with high radial performance: Potential for treatment of portal vein stenosis

Application of Additive Manufacturing in the Development of Polymeric Bioresorbable Cardiovascular Stents: A Review

Contact Info

Product

Resources

About