The regional fire protection plan is an important part of the city’s overall plan, which represents the deepening of the regional fire protection plan and the specific content of the city’s economic regional fire protection plan. Fire protection is an important part of national economic and social development, and it is also one of the indicators to measure the level of modern culture. Effective and practical fire protection planning can effectively prevent and reduce fire risks and protect the lives and property of the people, which is very important for social development. In order to optimize the regional fire model, this study uses a very objective fuzzy theory to analyze and discuss the research objects. In view of the large amount of fuzzy information in fuzzy optimization, fuzzy criterion recognition, and fuzzy grouping, based on the generalized fuzzy distance and fuzzy number, this paper proposes a multiobjective fuzzy theory-based comprehensive evaluation and optimization model of fire planning for major hazard sources. The results show that hotel fire risks tend to be higher, which is the focus of people’s attention. Among the fire hazards, wholesale, retail, and catering industries are the hardest hit areas, accounting for 66.3%, and some other industries are also disaster areas that need to be dealt with.