After the Second World War, technological advancements helped to develop agriculture and meet urgent food needs. The green revolution was based on the cultivation of new high-yielding varieties, the adoption of plant protection measures, and synthetic fertilizer use. Today, agriculture is called upon to recover its productivity in environmentally friendly terms and to face challenges such as climate change and international political–military events that threaten global sufficiency in agricultural products. The objective of the study is to evaluate the function that crop-protection technologies play in ensuring the continuity of agricultural output. The research was conducted by the use of a questionnaire in a sample of 250 farmers in Northern Greece. Specifically, through descriptive and regression analysis, the roles of biological crop protection, chemical crop-protection techniques, and mechanical crop-protection techniques were explored, and it was found that they either have a positive effect or a significant relationship with sustainable agricultural productivity. In order to meet the current environmental, economic, and political challenges, the agriculture sector at the global and local level should improve and further adopt existing technologies, consolidate the use of integrated pest-management strategies, and fully introduce innovations, combined with digital transformation, into agricultural management and production.