2016
DOI: 10.1016/j.apm.2016.07.010
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Multi-objective optimization of nonlinear switched time-delay systems in fed-batch process

Abstract: Maximization of productivity and minimization of consumption are two top priorities for biotechnological industry. In this paper, we model a fed-batch process as a nonlinear switched time-delay system. Taking the productivity of target product and the consumption rate of substrate as the objective functions, we present a multi-objective optimization problem involving the nonlinear switched time-delay system and subject to continuous state inequality constraints. To solve the multi-objective optimization proble… Show more

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Cited by 23 publications
(8 citation statements)
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“…For the multiobjective problems, previous studies suggest the gradient-based solution [24,25]. As described in [25], when the objective function is nondifferentiable, gradientbased optimization techniques are not suitable for dynamic programming models with constraints. Moreover, there are many potential local extrema in the charging model, and the gradient descent algorithm can easily lead to pseudoconvergence.…”
Section: Complexitymentioning
confidence: 99%
“…For the multiobjective problems, previous studies suggest the gradient-based solution [24,25]. As described in [25], when the objective function is nondifferentiable, gradientbased optimization techniques are not suitable for dynamic programming models with constraints. Moreover, there are many potential local extrema in the charging model, and the gradient descent algorithm can easily lead to pseudoconvergence.…”
Section: Complexitymentioning
confidence: 99%
“…, 10. The initial values of switching instants and terminal time [56] are listed in Table 3. It should be noted that these initial values of switching instants are obtained from Table 2.…”
Section: Phase Start Time (H) End Time (H)mentioning
confidence: 99%
“…Therefore, we just listed these six values and the other values of switching instants are missing entries (denoted by hyphens). The lower and upper bound vectors in (7) [56]. From vectors ρ and δ, we obtained the lower and upper bounds of switching instants and terminal time, which are also listed in Table 3.…”
Section: Phase Start Time (H) End Time (H)mentioning
confidence: 99%
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“…In fact, the optimal control problem considered in this paper has wide applications in the practical engineering; see, for example [10,23]. To solve these engineering problems using our developed computational method is our undergoing studies.…”
mentioning
confidence: 99%