Lithium battery pack, made of aluminum alloys, consisted of hundreds of welding seams. Due to the complicate distribution of welding seam and low stiffness of aluminum alloys, large welding deformation was found in the lithium battery pack. This paper analyzed the effect of welding parameters and the welding sequences on the deformation of lithium battery pack, then proposed a method to reduce the welding deformation of lithium battery pack maintaining the welding quality of single weld seam of aluminum alloys. By the coupling optimization of welding sequences and welding parameters, the welding deformation of lithium battery pack decreased from 1.69 to 1.29 mm with the reducing rate of 23.7% and hundreds of welding seams contours met the requirements of manufacturing quality. These findings could pave the way to improve the manufacturing quality of lithium battery pack made of aluminum alloys.