Multi-omics analyses of serum metabolome, urine metabolome and gut microbiome reveal dysregulated glycerophospholipid metabolism in subacute cadmium-exposed wistar rats

Maqin Xiaoke Granule Alleviates Acute Bronchitis Induced by Smoking Combined With Streptococcus pneumoniae by Regulating NLRP3/p38 MAPK/Glycerophospholipid Pathway

“…6-Benzylaminopurine can regulate lipid metabolism by altering genes associated with fatty acid and glycerophospholipid metabolism 31 ; subacute cadmium disrupts intestinal microecological balance and glycerophospholipid metabolic homeostasis. 32 In addition, there is growing evidence that inflammation is related to glycerophospholipid metabolism. Allergic asthma involves a variety of inflammatory cells PD00 can modulate glycerophospholipid and purine metabolic pathways to reduce allergic asthma inflammation, thereby improving the pathophysiological features of asthma 33 ; Dietary β-CG induced enterocolitis in different intestinal segments and altered glycerophospholipid metabolism and arginine biosynthesis pathways 34 ; OGPC down-regulated TNF-α induced IL-6 secretion in vitro, and OGPC associated with glycerophospholipid metabolism pathway was significantly reduced, and glycerophospholipid metabolism was the main metabolic pathway for IL-6 differential expression in rheumatoid arthritis patients 35 ; Sepsis is a severe inflammatory disease, and STV-Na significantly alters the synthesis of glycerophospholipid metabolism, among others thereby modulating inflammation in sepsis 36 ; by altering glycerophospholipid metabolism pathways, Herba patriniae significantly modulates lipid metabolism and inflammation levels, demonstrating the potential for antiatherosclerotic development.…”