Multi‑omics analysis of right ventricles in rat models of pulmonary arterial hypertension: Consideration of mitochondrial biogenesis by chrysin

Kobayashi, Takayuki; Kim, Jun-Dal; Naito, Akira; Yanagisawa, Akiko; Jujo, Takayuki; Kasuya, Yoshitoshi; Nakagawa, Yoshimi; Sakao, Seiichiro; Suzuki, Takuji

doi:10.3892/ijmm.2022.5124

Cited by 7 publications

(1 citation statement)

References 52 publications

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“…Fatty acid oxidation was impaired as well [92]. In PAH patients, right ventricular failure is linked to metabolic disarrangements in the cardiomyocytes, which are caused by reduced adenylate energy charge, as testified by metabolomics [93].…”

Section: Right Ventricular Functionmentioning

confidence: 98%

Metabolomics in Pulmonary Hypertension—A Useful Tool to Provide Insights into the Dark Side of a Tricky Pathology

Bassareo,

D’Alto

2023

IJMS

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Pulmonary hypertension (PH) is a multifaceted illness causing clinical manifestations like dyspnea, fatigue, and cyanosis. If left untreated, it often evolves into irreversible pulmonary arterial hypertension (PAH), leading to death. Metabolomics is a laboratory technique capable of providing insights into the metabolic pathways that are responsible for a number of physiologic or pathologic events through the analysis of a biological fluid (such as blood, urine, and sputum) using proton nuclear magnetic resonance spectroscopy or mass spectrometry. A systematic review was finalized according to the PRISMA scheme, with the goal of providing an overview of the research papers released up to now on the application of metabolomics to PH/PAH. So, eighty-five papers were identified, of which twenty-four concerning PH, and sixty-one regarding PAH. We found that, from a metabolic standpoint, the hallmarks of the disease onset and progression are an increase in glycolysis and impaired mitochondrial respiration. Oxidation is exacerbated as well. Specific metabolic fingerprints allow the characterization of some of the specific PH and PAH subtypes. Overall, metabolomics provides insights into the biological processes happening in the body of a subject suffering from PH/PAH. The disarranged metabolic pathways underpinning the disease may be the target of new therapeutic agents. Metabolomics will allow investigators to make a step forward towards personalized medicine.

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Section: Right Ventricular Functionmentioning

confidence: 98%