Multi-omics approaches in psychoneuroimmunology and health research: Conceptual considerations and methodological recommendations

Mengelkoch, Summer; Lautman, Ziv; Alley, Jenna; Roos, Lydia G.; Ehlert, Benjamin; Moriarity, Daniel P.; Lancaster, Samuel M.; Rose, Sophia Miryam Schüssler‐Fiorenza; Snyder, M; Slavich, George M.

doi:10.1016/j.bbi.2023.07.022

Cited by 17 publications

(13 citation statements)

References 102 publications

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“…Such research would be worth conducting, especially since the influence of the psyche on resistance to diseases is discussed more and more frequently. Psychoneuroimmunology dealing with this issue is a subdiscipline from the borderline of medicine and psychology (34,35).…”

Section: Resultsmentioning

confidence: 99%

The sense of loneliness and meaning in life in post-COVID convalescents—a preliminary study

Sipowicz,

Pietras,

Mosiołek

et al. 2023

Front. Psychiatry

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IntroductionThe COVID-19 epidemic has provided opportunity to study the impact of a well-defined severe illness on the development of a depressive episode and the associated sense of loneliness and lack of meaning in life.Materials and MethodsThe aim of the study was to assess the occurrence of a reactive depressive episode, the severity of depression, a sense of loneliness and meaning in life in subjects who approximately a year earlier than the date of the study had suffered from a pulmonary form of SARS-CoV-2 infection with radiologically documented interstitial lesions of the lungs, requiring and not requiring hospitalization compared to people who did not develop the disease as a result of infection with that virus. The study included 63 subjects hospitalized for pulmonary lesions, 67 not hospitalized and 60 healthy controls. The severity of depressive symptoms was measured using a Polish-language standardized version of the Beck Depression Inventory, a sense of loneliness using the De Jong Gierveld Loneliness Scale, and a sense of meaning in life using the Life Attitude Profile-Revised.ResultsThe frequency of depression and its severity were found to be the highest in hospitalized patients compared to those treated at home and healthy people. A significant difference in the frequency of depression and its severity between outpatients and healthy people was also observed. The feeling of loneliness turned out to be greatest in the group of hospitalized people. Also, the severity of loneliness was found to be higher in the outpatient compared to the control group. The sense of meaning in life reached its lowest level among hospitalized patients, was moderately reduced in the outpatient group, and typical of the Polish population in the control group.DiscussionBoth pulmonary SARS-CoV-2 infection and hospitalization have been shown to be a risk factor for depression, increased feeling of loneliness and a reduced sense of meaning in life. The effect of trauma and the presence of depression can be the explanation for the increased sense of loneliness after the illness and the partial breakdown of the lifeline manifested by a decrease in the sense of meaning in life.

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Section: Resultsmentioning

confidence: 99%

The sense of loneliness and meaning in life in post-COVID convalescents—a preliminary study

Sipowicz,

Pietras,

Mosiołek

et al. 2023

Front. Psychiatry

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“…This involves RNA sequencing (RNA-Seq) to quantify and characterize RNA transcripts. Transcriptomic analysis sheds light on the expression levels of genes and the presence of RNA splice variants, offering insights into how genetic variations translate into changes in mRNA expression [12,15].…”

Section: Methodological Framework Of Proteogenomicsmentioning

confidence: 99%

Proteogenomics in Nephrology: A New Frontier in Nephrological Research

Chavali,

Coker,

Youngblood

et al. 2024

CIMB

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Proteogenomics represents a transformative intersection in nephrology, uniting genomics, transcriptomics, and proteomics to unravel the molecular intricacies of kidney diseases. This review encapsulates the methodological essence of proteogenomics and its profound implications in chronic kidney disease (CKD) research. We explore the proteogenomic pipeline, highlighting the integrated analysis of genomic, transcriptomic, and proteomic data and its pivotal role in enhancing our understanding of kidney pathologies. Through case studies, we showcase the application of proteogenomics in clear cell renal cell carcinoma (ccRCC) and Autosomal Recessive Polycystic Kidney Disease (ARPKD), emphasizing its potential in personalized treatment strategies and biomarker discovery. The review also addresses the challenges in proteogenomic analysis, including data integration complexities and bioinformatics limitations, and proposes solutions for advancing the field. Ultimately, this review underscores the prospective future of proteogenomics in nephrology, particularly in advancing personalized medicine and providing novel therapeutic insights.

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“…However, teasing out the causal effect of inflammation in clinical populations is very difficult, given the large individual differences in individual differences in symptoms, comorbidities, and related medication, but also age-related diseases and biological changes, as well as lifestyle factors. Lifestyle factors can include nutrition, physical activity, alcohol, etc., and lately, environmental aspects are considered well [16]. Moreover, the studied processes change and adapt over time [14,[17][18][19].…”

Section: Crosstalk Between the Immune System And The Brainmentioning

confidence: 99%

How Can Experimental Endotoxemia Contribute to Our Understanding of Pain? A Narrative Review

Benson,

Karshikoff

2023

Neuroimmunomodulation

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Background: The immune system and the central nervous system exchange information continuously. This communication is a prerequisite for adaptive responses to physiological and psychological stressors. While the implicate relationship between inflammation and pain is increasingly recognized in clinical cohorts, the underlying mechanisms and the possibilities for pharmacological and psychological approaches aimed at neuro-immune communication in pain are not fully understood yet. This calls for preclinical models which build a bridge from clinical research to laboratory research. Summary: Experimental models of systemic inflammation (experimental endotoxemia) in humans have been increasingly recognized as an approach to study the direct and causal effects of inflammation on pain perception. This narrative review provides an overview of what experimental endotoxemia studies on pain have been able to clarify so far. We report that experimental endotoxemia results in a reproducible increase in pain sensitivity, particularly for pressure and visceral pain (deep pain), which is reflected in responses of brain areas involved in pain processing. Increased levels of blood inflammatory cytokines are required for this effect, but cytokine levels do not always predict pain intensity. We address sex-dependent differences in immunological responses to endotoxin, and discuss why these differences do not necessarily translate to differences in behavioral measures. We summarize psychological and cognitive factors that may moderate pain sensitization driven by immune activation. Key messages: Together, studying the immune-driven changes in pain during endotoxemia offers a deeper mechanistic understanding of the role of inflammation in chronic pain. Experimental endotoxemia models can specifically help to tease out inflammatory mechanisms underlying individual differences, vulnerabilities, and comorbid psychological problems in pain syndromes. The model offers the opportunity to test the efficacy of interventions, increasing their translational applicability for personalized medical approaches.

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Multi-omics approaches in psychoneuroimmunology and health research: Conceptual considerations and methodological recommendations

Cited by 17 publications

References 102 publications

The sense of loneliness and meaning in life in post-COVID convalescents—a preliminary study

The sense of loneliness and meaning in life in post-COVID convalescents—a preliminary study

Proteogenomics in Nephrology: A New Frontier in Nephrological Research

How Can Experimental Endotoxemia Contribute to Our Understanding of Pain? A Narrative Review

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