Multi-‘omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients

Developing a Blood Cell‐Based Diagnostic Test for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Peripheral Blood Mononuclear Cells

“…By quantifying levels of intracellular metabolites via PBMCs' Raman spectra, we observed metabolic differences between the ME/CFS and two control cohorts. Most of the metabolic changes that have been reported in previous ME/CFS studies of plasma are consistent with direct and indirect effects of energy strain [32][33][34][35][36] and abnormal lipid metabolism. [35][36][37][38][39] Our findings agree with the altered utilization of amino acids in patients with ME/CFS, including AAAs of tryptophan, tyrosine, and phenylalanine.…”

“…Most of the metabolic changes that have been reported in previous ME/CFS studies of plasma are consistent with direct and indirect effects of energy strain [32][33][34][35][36] and abnormal lipid metabolism. [35][36][37][38][39] Our findings agree with the altered utilization of amino acids in patients with ME/CFS, including AAAs of tryptophan, tyrosine, and phenylalanine. This was also shown in the MS group compared to healthy controls.…”

Integrated metabolomics and transcriptomics revealed the anti-constipation mechanisms of xylooligosaccharides from corn cobs

“…XOSs modulated the gut microbiota, promoting growth of beneficial bacteria, such as Bifidobacterium, and reducing harmful ones. 15 This modulation of the gut microbiota contributed to observed metabolic changes, including increased levels of butyrate, a known metabolite with beneficial effects on gut health 36 and constipation relief. 37 Butyric acid also enhanced immunological responses and intestinal inflammation, maintaining a healthy colonic environment.…”

Exercise training modifies xenometabolites in gut and circulation of lean and obese adults

“…While caffeine itself is not a microbial metabolite, other xanthine metabolites, including those upregulated in this study with exercise training, are known to be modified by microbial species (Zhou et al, 2020 ). Recent data indicates that changes in microbial xanthine metabolism is a key feature of select chronic states including chronic fatigue syndrome, where disease progression decreases microbial xanthine metabolism (Xiong et al, 2023 ). Conversely, the current study provides evidence that microbial xanthine metabolite production is increased in response to exercise training.…”