Multi-Parametric Single-Shot Magnetic Resonance Spectroscopy for Fast Metabolite-Specific Concentration and T2 Determination

Abstract

Multi-Echo Single-Shot (MESS) spectroscopy is tested in-vivo aiming at simultaneous determination of metabolite content and T2 times through simultaneous multi-parametric model fitting of partially sampled echoes. Cramer-Rao Lower Bounds (CRLBs) are used as measure of performances. The novel scheme was compared with the traditional Multi-Echo Multi-Shot (MEMS) method. Results confirmed former in-silico studies and indicate that MESS outperforms MEMS for simultaneous determinations of T2s and concentrations, with improvements ranging from 5-20% for T2s and 10-50% for concentrations.

Multi‐echo single‐shot spectroscopy combined with simultaneous 2D model fitting for fast and accurate measurement of metabolite‐specific concentrations and T2 relaxation times

“…22 In this work, we propose a novel acquisition scheme of acquiring multi-TE data in a single acquisition to be used in a combined fitting process, where the half echo of the shortest TE is fitted with the full echoes recorded for later TEs, including the extended tail of the last echo that provides resolution information for the whole echo train. 23 The multi-TE combined fit enables the simultaneous estimation of concentrations and T 2 s, deploying one single model equation. The primary goal of this study was to demonstrate the feasibility of simultaneous quantification of metabolite concentrations and metabolite-specific T 2 s by multi-echo single-shot (MESS) spectroscopy in a clinically compatible timeframe and to evaluate its performance against the traditional acquisition approach with separately recorded multiple echo spectra.…”

“…The multi‐TE combined fit enables the simultaneous estimation of concentrations and T 2 s, deploying one single model equation. The primary goal of this study was to demonstrate the feasibility of simultaneous quantification of metabolite concentrations and metabolite‐specific T 2 s by multi‐echo single‐shot (MESS) spectroscopy in a clinically compatible timeframe and to evaluate its performance against the traditional acquisition approach with separately recorded multiple echo spectra 24 …”