Multi-photon imaging of amine-functionalized silica nanoparticles

Natálio, Filipe; Kashyap, Anubha; Lorenz, Steffen; Kerschbaumer, Hannes; Dietzsch, Michael; Tahir, Muhammad Nawaz; Duschner, H.; Strand, Susanne; Strand, Dennis; Tremel, Wolfgang

doi:10.1039/c2nr30660c

Cited by 5 publications

(7 citation statements)

References 44 publications

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“…In comparison to conventional microscopy, multi-photon microcopy is superior regarding the reduced fluorescence background based on the little two photon-cross-section of most biomolecules leading to less auto-fluorescence, enhanced penetration depth within biological samples by tuning the excitation light to the biological window, near IR range 700–1000 nm. Furthermore, the effect of photobleaching can be reduced by selective excitation of the focal volume [ 93 – 94 ]. Nevertheless, it remains challenging to extend the technique to time-dependent measurements for clinically relevant volumes, reaching beyond small animals used as testing systems at the moment [ 95 – 98 ].…”

Section: Reviewmentioning

confidence: 99%

Inorganic Janus particles for biomedical applications

Schick¹,

Lorenz²,

Gehrig

et al. 2014

Beilstein J. Nanotechnol.

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SummaryBased on recent developments regarding the synthesis and design of Janus nanoparticles, they have attracted increased scientific interest due to their outstanding properties. There are several combinations of multicomponent hetero-nanostructures including either purely organic or inorganic, as well as composite organic–inorganic compounds. Janus particles are interconnected by solid state interfaces and, therefore, are distinguished by two physically or chemically distinct surfaces. They may be, for instance, hydrophilic on one side and hydrophobic on the other, thus, creating giant amphiphiles revealing the endeavor of self-assembly. Novel optical, electronic, magnetic, and superficial properties emerge in inorganic Janus particles from their dimensions and unique morphology at the nanoscale. As a result, inorganic Janus nanoparticles are highly versatile nanomaterials with great potential in different scientific and technological fields. In this paper, we highlight some advances in the synthesis of inorganic Janus nanoparticles, focusing on the heterogeneous nucleation technique and characteristics of the resulting high quality nanoparticles. The properties emphasized in this review range from the monodispersity and size-tunability and, therefore, precise control over size-dependent features, to the biomedical application as theranostic agents. Hence, we show their optical properties based on plasmonic resonance, the two-photon activity, the magnetic properties, as well as their biocompatibility and interaction with human blood serum.

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Section: Reviewmentioning

confidence: 99%

Inorganic Janus particles for biomedical applications

Schick¹,

Lorenz²,

Gehrig

et al. 2014

Beilstein J. Nanotechnol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Multiphoton imaging (MPI) helps in reducing the signal to noise ratio since auto fluorescence is minimized as biomolecules have a low two photon cross section. Instead of QDs doped with heavy metals, Natalio et al in their study confirmed that silica particles can be used in MPI after functionalizing with SOCl 2 and with N ‐Boc‐1,4‐butanediamine which introduces chlorine groups and amine groups on the surface, which further allows for conjugation of biomolecules 33. The SiO 2 ‐N gives fluorescence characteristics to the NPs.…”

Section: Functionalization To Enhance Imagingmentioning

confidence: 99%

Nanoparticle Functionalization and Its Potentials for Molecular Imaging

et al. 2016

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Functionalization enhances the properties and characteristics of nanoparticles through surface modification, and enables them to play a major role in the field of medicine. In molecular imaging, quality functional images are required with proper differentiation which can be seen with high contrast to obtain viable information. This review article discusses how functionalization enhances molecular imaging and enables multimodal imaging by which images with combination of functions particular to each modality can be obtained. This also explains how nanoparticles interacting at molecular level, when functionalized with molecules can target the cells of interest or substances with high specificity, reducing background signal and allowing simultaneous therapies to be carried out while imaging. Functionalization allows imaging for a prolonged period and enables to track the cells over a period of time. Recent researches and progress in functionalizing the nanoparticles to specifically enhance bioimaging with different modalities and their applications are reviewed in this article.

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“…Two‐photon–cross‐section of most biomolecules is more ideal as it leads to less autofluorescence and an improved penetration depth. Photo‐bleaching effect is also decreased by selective excitation of the focal volume …”

Section: Applications Of Magnetic Jpsmentioning

confidence: 99%

Magnetic Anisotropic Particles: Toward Remotely Actuated Applications

Teo

Young

Loh

2016

Part & Part Syst Charact

100

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The latest breakthroughs in the synthetic preparation of nanomaterials have led to an expanding library of novel, complex and shape controlled structures with unique characteristics. Anisotropic Janus particles (JPs) are asymmetrical and are able to endow diverse chemical and physical characteristics with directionality within a single particle. They are typically distributed into three classes, viz polymeric, inorganic and polymeric‐inorganic and is made in a variation of morphologies including spherical, mushroom, snowman shaped, rod or cylindrical. Herein, we focus on JPs with a magnetic component, with emphasis on their fabrication, unique characteristics and recent applications.

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Multi-photon imaging of amine-functionalized silica nanoparticles

Cited by 5 publications

References 44 publications

Inorganic Janus particles for biomedical applications

Inorganic Janus particles for biomedical applications

Nanoparticle Functionalization and Its Potentials for Molecular Imaging

Magnetic Anisotropic Particles: Toward Remotely Actuated Applications

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