Multi-residue method for determination of seven neonicotinoid insecticides in grains using dispersive solid-phase extraction and dispersive liquid–liquid micro-extraction by high performance liquid chromatography

Wang, P.; Yang, Xin; Wang, J.; Cui, Jing; Dong, Anjie; Zhao, Haitian; Zhang, L.W.; Wang, Zeyu; Xu, Ronghui; Li, W.J.; Zhang, Y.C.; Zhang, Haimo; Jing, Junjie

doi:10.1016/j.foodchem.2012.03.103

Cited by 149 publications

(64 citation statements)

References 33 publications

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“…In these methods, but also in methods for the analysis of simpler matrices of interest (i.e., honey [36,37], fruits [38][39][40][41][42], or vegetables [41][42][43][44][45][46][47]), great effort has been devoted to both extraction and cleanup procedures that precede instrumental analysis [48]. To obtain satisfactory recovery factors for both neonicotinoids and their main metabolites, several versions of the quick, easy, cheap, effective, rugged, and safe (QuEChERS) method originally proposed by Anastassiades et al [49] were developed [33,35,37,40,46].…”

Section: Introductionmentioning

confidence: 99%

UHPLC-DAD method for the determination of neonicotinoid insecticides in single bees and its relevance in honeybee colony loss investigations

et al. 2012

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In the understanding of colony loss phenomena, a worldwide crisis of honeybee colonies which has serious consequences for both apiculture and bee-pollination-dependent farm production, analytical chemistry can play an important role. For instance, rapid and accurate analytical procedures are currently required to better assess the effects of neonicotinoid insecticides on honeybee health. Since their introduction in agriculture, neonicotinoid insecticides have been blamed for being highly toxic to honeybees, possibly at the nanogram per bee level or lower. As a consequence, most of the analytical methods recently optimized have focused on the analysis of ultratraces of neonicotinoids using liquid chromatography-mass spectrometry techniques to study the effects of sublethal doses. However, recent evidences on two novel routes-seedling guttations and seed coating particulate, both associated with corn crops-that may expose honeybees to huge amounts of neonicotinoids in the field, with instantly lethal effects, suggest that selected procedures need optimizing. In the present work, a simplified ultra-high-performance liquid chromatography-diode-array detection method for the determination of neonicotinoids in single bees has been optimized and validated. The method ensures good selectivity, good accuracy, and adequate detection limits, which make it suitable for the purpose, while maintaining its ability to evaluate exposure variability of individual bees. It has been successfully applied to the analysis of bees in free flight over an experimental sowing field, with the bees therefore being exposed to seed coating particulate released by the pneumatic drilling machine.

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Section: Introductionmentioning

confidence: 99%

UHPLC-DAD method for the determination of neonicotinoid insecticides in single bees and its relevance in honeybee colony loss investigations

et al. 2012

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“…The extraction efficiency of the proposed QuEChERS-LDS-DLLME procedure has been compared with other similar techniques recently reported utilizing QuEChERS [3,23,25,30,34] and QuEChERS-DLLME [47] in terms of the parameters such as linearity ranges, LOD, and %R. Details of the comparison are shown in Table 4.…”

Section: Comparison Of the Proposed Methods With Other Reported Methodsmentioning

confidence: 99%

“…With lower volumes, the extraction solvent may not properly be dispersed and thus as a consequence, the transfer of the analytes from aqueous sample to the organic phase decreases. On the other hand, the decrease in the peak areas of the target analytes at higher volumes of the extraction solvent could be attributed to the reduction of the enrichment factors (or dilution effect), resulting from the increase in the volume of organic phase collected after extraction [35,46,47]. Thus, 125 µL of diexhyl ether was chosen as the optimum volume in all the subsequent experiments.…”

Section: Selection Of Volume Of the Extraction Solventmentioning

confidence: 99%

The QuEChERS analytical method combined with low density solvent based dispersive liquid–liquid microextraction for quantitative extraction of multiclass pesticide residues in cereals

Bedassa¹,

Gure²,

Megersa³

2017

Bull. Chem. Soc. Eth.

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ABSTRACT. In this study, a combination QuEChERS and low density solvent based DLLME was developed for extraction and preconcentration of five multiclass pesticide residues including atrazine, ametryn, terbutryn, carbaryl and chlorothalonil, from selected cereals: Teff, barley and maize samples. Liquid chromatography with variable wavelength detector (VWD) was used for quantitative determination of the pesticides. Various experimental parameters affecting the extraction and the preconcentration efficiencies were optimized. Calibration curves constructed using Teff samples were linear over wide ranges, 7.1-200 μg kg -1 with R 2 ≥ 0.990. LODs of the method were ≤ 8.9 μg kg -1 , below the MRLs of EU for maize and barley. The RSDs were in the range of 2.3-9.5%. The method has also been applied to different cereal samples and satisfactory average recoveries ranging 69.0-117% were obtained for the spiked cereal samples at two concentration levels. Therefore, the developed method can be successfully utilized as a simple alternative for the analysis of multiclass pesticide residues in cereals and other related samples.

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“…The national standard for food safety published in China stipulates that the MRLs for thiamethoxam in cucumber and brown rice are 0.5 mg kg À1 and 0.1 mg kg À1 . The existing analytical techniques for the analysis of thiamethoxam mainly include highperformance liquid chromatography (HPLC), 6,7 liquid chromatography and mass spectrometry. 8 Despite being sensitive and specic, all these methods require expensive equipment, highly trained personnel, and time-consuming pretreatment.…”

Section: Introductionmentioning

confidence: 99%

A facile molecularly imprinted electrochemical sensor based on graphene: application to the selective determination of thiamethoxam in grain

et al. 2017

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aIn this study, we report a facile method for the preparation of molecularly imprinted polymer based graphene for the electrochemical detection of thiamethoxam residue. We choose p-vinylbenzoic acid as a functional monomer; it can be used to add recognition units and alkenyl units onto the surface of graphene via p-p interactions in just one step, effectively simplifying the reaction process. And an ultrathin imprinting film (2 nm) is formed by reducing the addition step involving the alkenyl modifier. Due to the irreversible electrochemical reduction characteristics of thiamethoxam, the template can be removed easily using cyclic voltammetry scanning, without the need for organic solvents. The performance of the fabricated sensor was evaluated and the results indicated that the sensor exhibited excellent specific recognition abilities for thiamethoxam detection; the imprinting factor is 2.36. The peak current from thiamethoxam is linearly proportional to its concentration over the range from 0.5 to 20 mM, and the detection limit is 0.04 mM. The practical application of the sensor was also realized in the selective detection of thiamethoxam in real samples.

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Multi-residue method for determination of seven neonicotinoid insecticides in grains using dispersive solid-phase extraction and dispersive liquid–liquid micro-extraction by high performance liquid chromatography

Cited by 149 publications

References 33 publications

UHPLC-DAD method for the determination of neonicotinoid insecticides in single bees and its relevance in honeybee colony loss investigations

UHPLC-DAD method for the determination of neonicotinoid insecticides in single bees and its relevance in honeybee colony loss investigations

The QuEChERS analytical method combined with low density solvent based dispersive liquid–liquid microextraction for quantitative extraction of multiclass pesticide residues in cereals

A facile molecularly imprinted electrochemical sensor based on graphene: application to the selective determination of thiamethoxam in grain

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