Multi-residue method for the determination of antibiotics and some of their metabolites in seafood

Serra-Compte, Albert; Álvarez-Muñoz, Diana; Rodríguez-Mozaz, Sara; Barceló, Damià

doi:10.1016/j.fct.2016.11.031

Cited by 57 publications

(29 citation statements)

References 46 publications

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“…For example, atenolol showed MS signal enhancement in extracts of one species and suppression in another, using the same salts ( Berlioz-Barbier et al., 2014 ). The addition of chelating ligands such as ethylenediaminetetraacetic acid (EDTA) can also improve extraction efficiency of some compounds which readily form complexes with matrices containing metals ( Serra-Compte et al., 2017 ; Dasenaki and Thomaidis, 2015 ). Therefore, analytical methods that have been developed using one matrix may not show the same performance for another and methods need to be assessed carefully before application.…”

Section: Pre-treatment Methods For Pharmaceutical Residues In Fish Anmentioning

confidence: 99%

A review of the pharmaceutical exposome in aquatic fauna

Miller

Bury

Owen

et al. 2018

Environmental Pollution

219

107

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Pharmaceuticals have been considered ‘contaminants of emerging concern’ for more than 20 years. In that time, many laboratory studies have sought to identify hazard and assess risk in the aquatic environment, whilst field studies have searched for targeted candidates and occurrence trends using advanced analytical techniques. However, a lack of a systematic approach to the detection and quantification of pharmaceuticals has provided a fragmented literature of serendipitous approaches. Evaluation of the extent of the risk for the plethora of human and veterinary pharmaceuticals available requires the reliable measurement of trace levels of contaminants across different environmental compartments (water, sediment, biota - of which biota has been largely neglected). The focus on pharmaceutical concentrations in surface waters and other exposure media have therefore limited both the characterisation of the exposome in aquatic wildlife and the understanding of cause and effect relationships. Here, we compile the current analytical approaches and available occurrence and accumulation data in biota to review the current state of research in the field. Our analysis provides evidence in support of the ‘Matthew Effect’ and raises critical questions about the use of targeted analyte lists for biomonitoring. We provide six recommendations to stimulate and improve future research avenues.

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Section: Pre-treatment Methods For Pharmaceutical Residues In Fish Anmentioning

confidence: 99%

A review of the pharmaceutical exposome in aquatic fauna

Miller

Bury

Owen

et al. 2018

Environmental Pollution

219

107

View full text Add to dashboard Cite

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“…Antibiotics accumulation in marine mussels has been previously reported 14,15 . For instance, sulfamethoxazole (SMX) antibiotic has been found in the marine environment 15 , and accumulated in commercial aquatic organisms, up to 245.91 ng/g in Pangasius from Thailand 16 .…”

Section: Introductionmentioning

confidence: 96%

Exposure to a Subinhibitory Sulfonamide Concentration Promotes the Spread of Antibiotic Resistance in Marine Blue Mussels (Mytilus edulis)

Serra-Compte

Sànchez-Melsió

Álvarez-Muñoz

et al. 2019

Environ. Sci. Technol. Lett.

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Although antibiotic resistance has become a significant and growing threat to public and environmental health, the occurrence and prevalence of this phenomenon in seafood has not been extensively explored. This study aims to evaluate the impact of sub-inhibitory antibiotic concentrations on the spread of antibiotic resistance in mussels. Marine blue mussels were exposed to sulfamethoxazole (SMX) at 100 μg/L; then, the presence of genes conferring resistance to sulfonamides (sul1 and sul2) and the class 1 integronintegrase gene (intI1), as well as bacterial community composition associated with the gastrointestinal tract were investigated. Results showed that all analyzed genes were present in mussels, even in those non-exposed to SMX. Moreover, an exposure to SMX caused a significant increase in the absolute copy number of sul1 in mussels, although no significant changes were observed in sul2 and intI1 genes. Because bacterial community composition was not affected after SMX exposure, the increase of sul1 may be attributed to its spread within mussel's microbiome due to the pressure exerted by SMX pollution. Overall, our results showed the presence of antibiotic resistance genes (ARGs) in blue mussels, and highlighted the contribution of anthropogenic pollution to the spread of ARGs in aquatic organisms.

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“…The quick, easy, cheap, effective, rugged and safe (QuEChERS) method introduced to improve extraction efficiency and to elevate method reliability in a great variety of samples, has been significantly developed and successfully applied in the residues analytical field (Garcia & Gotah, 2017;Serra-Compte et al, 2017). To our knowledge, previous researchers always focused on one sample type or a single class of veterinary drugs.…”

Section: Introductionmentioning

confidence: 99%

Screening of 49 antibiotic residues in aquatic products using modified QuEChERS sample preparation and UPLC-QToFMS analysis

Gao

Zhang

Huang

et al. 2021

PeerJ Analytical Chemistry

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A precise analytical method was established for rapid screening of 49 antibiotic residues in aquatic products by ultra-high performance liquid chromatography-quadrupole time of flight mass spectrometry (UPLC-QToFMS). The quick, easy, cheap, effective, rugged and safe (QuEChERS) process was refined for effective sample preparation. The homogenized samples of aquatic products were extracted with 3% acetic acid in acetonitrile, salted out with anhydrous magnesium sulfate and sodium chloride, and cleaned up by octadecylsilane (C18) and primary-secondary amine (PSA) powder. Then, the purified samples were separated on a BEH C18 column using 0.1% formic acid and methanol as mobile phases by gradient elution, detected by MS under positive Electron Spray Ionization (ESI+) mode. The linear range of matrix-matched calibration curve was 1–100 μg/L for each compound with the correlation coefficients in the range of 0.9851–0.9999. The recoveries of target antibiotics at the different spiked levels ranged from 60.2% to 117.9% except for lincomycin hydrochloride, whereas relative standard deviations (RSDs) were between 1.6% and 14.0% except for sulfaguanidine in grass Carp, Penaeus vannamei and Scylla serrata matrices. The limits of detection (LODs) (S/N = 3) for the analytes were 0.05–2.40 μg/kg, 0.08–2.00 μg/kg and 0.10–2.27 μg/kg and the limits of quantification (LOQs) (S/N = 10) were 0.16–8.00 μg/kg, 0.25–6.66 μg/kg and 0.32–7.56 μg/kg in grass Carp, Penaeus vannamei and Scylla serrata, respectively. The method was successfully applied to grass Carp, Penaeus vannamei and Scylla serrata, demonstrating its ability for the determination of multi-categories antibiotic residues in aquatic products.

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Multi-residue method for the determination of antibiotics and some of their metabolites in seafood

Cited by 57 publications

References 46 publications

A review of the pharmaceutical exposome in aquatic fauna

A review of the pharmaceutical exposome in aquatic fauna

Exposure to a Subinhibitory Sulfonamide Concentration Promotes the Spread of Antibiotic Resistance in Marine Blue Mussels (Mytilus edulis)

Screening of 49 antibiotic residues in aquatic products using modified QuEChERS sample preparation and UPLC-QToFMS analysis

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