Multi‐response optimisation of ultrasound‐assisted extraction for recovery of flavonoids from red grape skins using response surface methodology

Tomaz, Ivana; Maslov, Luna; Stupić, Domagoj; Preiner, Darko; Ašperger, Danijela; Kontić, Jasminka Karoglan

doi:10.1002/pca.2582

Cited by 31 publications

(19 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This heating technique uses microwave energy and is based on the direct effect of microwaves on dipole polarization and ion conduction molecules [105][106][107] (Figure 2). The extraction of flavonoids may be affected by a large number of parameters, among the most important of which are: Time, temperature, plant material-solvent ratio, solvent concentration, solvent polarity, irradiation, frequency of intensity, and microwave power [63,106,[108][109][110].…”

Section: Microwave-assisted Extractionmentioning

confidence: 99%

Conventional and Emerging Extraction Processes of Flavonoids

et al. 2020

View full text Add to dashboard Cite

Flavonoids are a group of plant constituents called phenolic compounds and correspond to the nonenergy part of the human diet. Flavonoids are found in vegetables, seeds, fruits, and beverages such as wine and beer. Over 7000 flavonoids have been identified and they have been considered substances with a beneficial action on human health, particularly of multiple positive effects because of their antioxidant and free radical scavenging action. Although several studies indicate that some flavonoids have provident actions, they occur only at high doses, confirming in most investigations the existence of anti-inflammatory effects, antiviral or anti-allergic, and their protective role against cardiovascular disease, cancer, and various pathologies. Flavonoids are generally removed by chemical methods using solvents and traditional processes, which besides being expensive, involve long periods of time and affect the bioactivity of such compounds. Recently, efforts to develop biotechnological strategies to reduce or eliminate the use of toxic solvents have been reported, reducing processing time and maintaining the bioactivity of the compounds. In this paper, we review, analyze, and discuss methodologies for biotechnological recovery/extraction of flavonoids from agro-industrial residues, describing the advances and challenges in the topic.

show abstract

Section: Microwave-assisted Extractionmentioning

confidence: 99%

Conventional and Emerging Extraction Processes of Flavonoids

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Increasing the bioactive compounds in extracts is a challenging, but an inspiring task (Cujic et al ., ; Palma et al, ). The most appropriate approach is through experimental design and response surface methodology, which are commonly used to optimize extractions of phenolic compounds from plants (Tomaz et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Optimization of Aqueous Extraction from Kalanchoe pinnata Leaves to Obtain the Highest Content of an Anti‐inflammatory Flavonoid using a Response Surface Model

Nascimento

Aguiar

Leal-Costa³

et al. 2018

Phytochemical Analysis

View full text Add to dashboard Cite

show abstract

“…For solvent to feed ratios below 300, only reduced yields were achieved. Several authors also reported a dependency of extraction yield on solvent to feed ratio . Similarly, they found that an increase of solvent to feed ratio generally leads to an increase of the yield of the target compound.…”

Section: Resultsmentioning

confidence: 88%

Solvent accessibility limitation by plant matrix compounds in extraction of rutin from Solanum lycopersicum

Lück

Bergs

Jupke

2020

Separation Science Plus

View full text Add to dashboard Cite

Extraction procedures for plant‐based secondary metabolites are mainly influenced by choice of solvent, particle size and solvent to feed ratio. For developing an extraction protocol design‐of‐experiments or model‐based approaches have widely been used. Botanical aspects such as the influence of side compounds are less investigated. Either for analytical or preparative purposes, knowledge of the underlying extraction mechanisms is required to improve the process development. In this work, we demonstrate the mechanism of accessibility limitation of rutin by side compounds depending on the solvent to feed ratio. Extraction yields of target and side compounds are analyzed to derive correlations. The role of side compounds as limiting factors for target compound accessibility is demonstrated by performing two extraction steps using three different plant species. The maximum extraction yield of rutin is reached using a solvent to feed ratio of at least 300 for all three investigated plant species, while side compounds in liquid state generally affect the extractability of rutin. Phosphatidylcholines are identified as possible accessibility‐limiting compounds. In conclusion, the yields of target and side compounds strongly depend on the solvent to feed ratio, while side compounds cover the target compound in dry matter, reducing its accessibility.

show abstract

Multi‐response optimisation of ultrasound‐assisted extraction for recovery of flavonoids from red grape skins using response surface methodology

Cited by 31 publications

References 21 publications

Conventional and Emerging Extraction Processes of Flavonoids

Conventional and Emerging Extraction Processes of Flavonoids

Optimization of Aqueous Extraction from Kalanchoe pinnata Leaves to Obtain the Highest Content of an Anti‐inflammatory Flavonoid using a Response Surface Model

Solvent accessibility limitation by plant matrix compounds in extraction of rutin from Solanum lycopersicum

Contact Info

Product

Resources

About