Multi‐responsive hydrogels based on <i>N</i>‐isopropylacrylamide and sodium alginate

Dumitriu, Raluca Petronela; Mitchell, Geoffrey R.; Vasile, Cornelia

doi:10.1002/pi.2929

Cited by 79 publications

(54 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This explanation is supported by previous reports, showing that SA inclusion into PNIPAM networks led to an increased water swelling degree [33][34][35].…”

Section: Resultssupporting

confidence: 85%

“…All these properties have led to frequently use of SA in various medical applications, including hydrogel formulations based on SA alone or in association with various other polymers [29][30][31]. From this point of view, three types of structurally different hydrogels containing both SA and PNIPAM blocks have been reported in literature up to now: (a) hydrogels based on linear PNIPAM and Ca 2þ -crosslinked sodium alginate [32]; (b) hydrogels based on covalently crosslinked PNIPAM and linear SA [33][34][35][36]; and (c) hydrogels from SA-graft-PNIPAM copolymers [37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Novel Thermoreversible Injectable Hydrogel Formulations Based on Sodium Alginate and Poly(N-Isopropylacrylamide)

Teodorescu

Mihai

Turturicǎ

et al. 2015

International Journal of Polymeric Materials and Polymeric Biom

View full text Add to dashboard Cite

Novel injectable thermoreversible hydrogel compositions with semi-interpenetrating network structure were prepared through the addition of sodium alginate (SA) to poly(N-isopropylacrylamide) (PNIPAM) aqueous solutions. The addition of the hydrophilic alginate strongly improved the stability against syneresis of the 15 wt% PNIPAM hydrogels formed at 37 C from less than 15 min in the absence of alginate to more than 7 days in the presence of 4 wt% SA. Besides the SA concentration, the hydrogel stability depended on the molecular weight and polydispersity of PNIPAM, being lower when a high molecular weight fraction was present. The phase transition temperature (T ph ) of the PNIPAM aqueous solutions decreased with alginate concentration, while the dynamic viscosity and elastic modulus of the hydrogels increased. By decreasing the PNIPAM molecular weight and polydispersity, the dynamic viscosity and elastic modulus of the PNIPAM-alginate hydrogels formed above T ph diminished, while their viscoelastic behavior changed from predominantly elastic to predominantly viscous.

show abstract

“…This explanation is supported by previous reports, showing that SA inclusion into PNIPAM networks led to an increased water swelling degree [33][34][35].…”

Section: Resultssupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Novel Thermoreversible Injectable Hydrogel Formulations Based on Sodium Alginate and Poly(N-Isopropylacrylamide)

Teodorescu

Mihai

Turturicǎ

et al. 2015

International Journal of Polymeric Materials and Polymeric Biom

View full text Add to dashboard Cite

show abstract

“…The higher the alginates content in the semi-IPN hydrogels, the higher the sensitivity of the semi-IPN hydrogel. Dumitriu et al prepared a novel covalently cross-linked PNIPAAm/alginate "mixed-IPN" hydrogels [32]. Although ionic cross-linking of alginate is the most widely spread approach in the formation of alginate hydrogel, covalent cross-linking could be also applied.…”

Section: Strategies For Synthesis Of Pnipaam-based Hydrogelsmentioning

confidence: 99%

Novel Synthesis Pathways for PNIPAAm-Based Hydrogels and Their Application in Thermosensitive Textiles

Jovančić

Petruš̆̌̌̌ić

Molina

2014

Handbook of Smart Textiles

View full text Add to dashboard Cite

The research focus is lately directed towards the development of the thermosensitive textiles with advanced functionalities. As sources of inspiration for a progress in the field of these innovative materials, stimuli-sensitive polymer engineering, plasma surface engineering, and nanotechnology have been extensively explored. In this work, the polymerization methods for synthesis of Poly(N-isopropylacrylamide), PNIPAAm-based hydrogels, incorporating natural biopolymers (chitosan and b-cyclodextrin), for achieving dual temperature/pH sensitivity and improvement of relevant loading capacity towards specific guest molecules are outlined. These PNIPAAm-based hydrogels are of great interest for biomedical applications (transdermal drug delivery, cell encapsulation, wound dressing, tissue repair, etc.) and intelligent stimuli-sensitive textile coatings for moisture regain control, antimicrobial properties, water and/or oil repellency, and fragrance release. The strategies for synthesis of PNIPAAm-based hydrogels (macro and micro forms) and their proper integration onto textiles through the plasma surface modification, graft polymerization, and coatings are discussed. Novel possibilities for creating hydrogels based on atmospheric plasma polymerization of NIPAAm monomers in liquids have alos been reported. Plasma polymerization in liquids demonstrated a great technological potential given that it may be performed without the use of chemical initiators and even without cross-linking agents, offering multiple advantages over the conventional hydrothermal polymerization methods. Further research on adequate chemical and physical structures of PNIPAAm-based hydrogels and methods of their applications in textiles could boost a progress in the domain of smart textiles, implying novel performances and end uses.

show abstract

“…In recent years, stimuli‐responsive hydrogels based on synthetic polymers, which are sensitive to the surrounding environment, have been extensively studied owing to their potential applications in the biomedical field . Among smart materials, temperature or/and pH responsive hydrogels are the most widely investigated because these two factors can be easily controlled and they are very important physiological parameters of human and biological systems …”

Section: Introductionmentioning

confidence: 99%

Temperature and pH responsive hydrogels based on polyethylene glycol analogues and poly(methacrylic acid) via click chemistry

Sheng

Liu

et al. 2015

Polymer International

View full text Add to dashboard Cite

A novel temperature responsive copolymer, poly[2-(2-methoxyethoxy)ethyl methacrylate-co-oligo(ethylene glycol) methacrylate-co-N-hydroxymethyl acrylamide] [P(MEO 2 MA-co-OEGMA-co-HMAM)], was synthesized by atom transfer radical polymerization. pH responsive poly(methacrylic acid) (PMAA) was synthesized by reversible addition-fragmentation chain transfer polymerization. After the hydroxyl groups on P(MEO 2 MA-co-OEGMA-co-HMAM) were transformed into azide groups and the carboxyl groups on PMAA were transformed into alkyne groups respectively, a novel temperature and pH responsive hydrogel was fabricated by click chemistry between the azide-P(MEO 2 MA-co-OEGMA-co-HMAM) and alkyne-PMAA in the presence of CuSO 4 and sodium ascorbate in aqueous solution. The rheological kinetics of gel formation demonstrated that gelation had commenced within 5 min at 25 ∘ C, since then the storage modulus (G ′ ) was higher than the loss modulus (G ′′ ). SEM images of hydrogel morphology and the swelling ratios of hydrogel at different temperatures and pH proved that the formed hydrogel had temperature and pH sensitivities. Bovine serum albumin was used as a model to evaluate the sustained release of the hydrogel; the results indicated that the hydrogel was a promising candidate for controlling protein drug delivery.

show abstract

Multi‐responsive hydrogels based on N‐isopropylacrylamide and sodium alginate

Cited by 79 publications

References 70 publications

Novel Thermoreversible Injectable Hydrogel Formulations Based on Sodium Alginate and Poly(N-Isopropylacrylamide)

Novel Thermoreversible Injectable Hydrogel Formulations Based on Sodium Alginate and Poly(N-Isopropylacrylamide)

Novel Synthesis Pathways for PNIPAAm-Based Hydrogels and Their Application in Thermosensitive Textiles

Temperature and pH responsive hydrogels based on polyethylene glycol analogues and poly(methacrylic acid) via click chemistry

Contact Info

Product

Resources

About