Nowadays, with progresses in robotic science, the design and implementation of a mechanism for human–robot interaction with a low workload is inevitable. One notable challenge in this field is the interaction between a single human and a group of robots. Therefore, we propose a new comprehensive framework for single‐human multiple‐robot remote interaction that can form an efficient intelligent adaptive interaction (IAI). Our interaction system can thoroughly adapt itself to changes in interaction context and user states. Some advantages of our devised IAI framework are lower workload, higher level of situation awareness, and efficient interaction. In this paper, we introduce a new IAI architecture as our comprehensive mechanism. In order to practically examine the architecture, we implemented our proposed IAI to control a group of unmanned aerial vehicles (UAVs) under different scenarios. The results show that our devised IAI framework can effectively reduce human workload and the level of situation awareness, and concurrently foster the mission completion percentage of the UAVs.