The multiscale model of building structures, as a balanced solution between accuracy and cost, has been widely used in the analysis of structural seismic performance. A reasonable interface connection method can accurately ensure load transfer and motion coordination between models of different scales. In this paper, a novel interface connection device and the corresponding design method for a multiscale test model of building structures were proposed, in which the upper structure with smaller sized components was replaced by a simplified story‐scale model, and the lower structure was adopted as a component‐scale model. The overall and local equations of motion for this multiscale model were established. For the interface connection between different scale models, a design method considering multiparametric similarity of shear force, axial force, and bending moment was proposed. In this method, the internal nodes at the interface of the component scale model were decomposed, and the coupling relationship of internal force between two adjacent nodes was established. The axial force of each node was decoupled into the interstory shear force and bending moment provided together. Additionally, the overturning moment is provided by adding the overlapping domain. According to the equilibrium relationships of the nodes at the interface, the corresponding transfer matrix was provided, and the design method of the interface connection device was proposed. The accuracy and feasibility of the method were validated by static and shaking table tests on a frame structure.