Multi-Scale and Multi-Physics Models of the Transport of Therapeutic/Diagnostic Cancer Agents

Moradi Kashkooli, Farshad; Kolios, Michael C.

doi:10.3390/cancers15245850

Cancers

2023

DOI: 10.3390/cancers15245850

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Multi-Scale and Multi-Physics Models of the Transport of Therapeutic/Diagnostic Cancer Agents

Farshad Moradi Kashkooli,

Michael C. Kolios

Abstract: The effectiveness of tumor treatment heavily relies on the successful delivery of anticancer drugs [...]

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2024

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Development of an ultrasound-mediated nano-sized drug-delivery system for cancer treatment: from theory to experiment

Kashkooli,

Jakhmola,

A Ferrier

et al. 2024

Nanomedicine

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Aim: To establish a methodology for understanding how ultrasound (US) induces drug release from nano-sized drug-delivery systems (NSDDSs) and enhances drug penetration and uptake in tumors. This aims to advance cancer treatment strategies. Materials & methods: We developed a multi-physics mathematical model to elucidate and understand the intricate mechanisms governing drug release, transport and delivery. Unique in vitro models (monolayer, multilayer, spheroid) and a tailored US exposure setup were introduced to evaluate drug penetration and uptake. Results: The results highlight the potential advantages of US-mediated NSDDSs over conventional NSDDSs and chemotherapy, notably in enhancing drug release and inducing cell death. Conclusion: Our sophisticated numerical and experimental methods aid in determining and quantifying drug penetration and uptake into solid tumors.

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Development of an ultrasound-mediated nano-sized drug-delivery system for cancer treatment: from theory to experiment

Kashkooli,

Jakhmola,

A Ferrier

et al. 2024

Nanomedicine

View full text Add to dashboard Cite

show abstract

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Multi-Scale and Multi-Physics Models of the Transport of Therapeutic/Diagnostic Cancer Agents

Abstract: The effectiveness of tumor treatment heavily relies on the successful delivery of anticancer drugs [...]

Cited by 1 publication

References 45 publications

Development of an ultrasound-mediated nano-sized drug-delivery system for cancer treatment: from theory to experiment

Development of an ultrasound-mediated nano-sized drug-delivery system for cancer treatment: from theory to experiment

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