Multi-scale biological and physical modelling of the tumour micro-environment

Abstract

Paced by advances in high performance computing, and algorithms for multi-physics and multi-scale simulation, a number of groups have recently established numerical models of flowing blood systems, where cellscale interactions are explicitly resolved. To be biologically representative, these models account for some or all of: (1) fluid dynamics of the carrier flow, (2) structural dynamics of the cells and vessel walls, (3) interaction and transport biochemistry, and, (4) methods for scaling to physiologically representative numbers of cells. In this article, our interest is the modelling of the tumour micro-environment. We review the broader area of cell-scale resolving blood flow modelling, while focusing on the particular interactions of tumour cells and white blood cells, known to play an important role in metastasis.

Multiscale modeling in smart cities: A survey on applications, current trends, and challenges

“…MM approaches that incorporate biological and physical modeling are commonly used to study the tumor microenvironment. F. Kunz et al focused their work [79] on a multiscale approach to melanoma metastasis in which tumor cells interact with polymorphonuclear neutrophils. Finally, the latest technological biochemistry and structural models related to the tumor environment at the micro level and cell growth and population at the macro level have been summarized.…”