Multi-scale cellular PLA-based bionic scaffold to promote bone regrowth and repair

Li, Zhong‐Ming; Tang, Shan; Shi, Z.; Li, Bin; Feng, Dong; Xie, Delong; Han, Tao; Li, Chengyong

doi:10.1016/j.ijbiomac.2023.125511

Cited by 7 publications

(6 citation statements)

References 44 publications

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“…As a cytoskeleton protein, the abundant expression of fibrous actin (F-actin) contributes to the crawling, migration, and attachment of osteoblasts. 60 All the four groups of composite scaffolds showed good F-actin induction, and cells showed excellent spreading and adhesion, which could be associated with the ECM-mimicking nanofibers in the composite scaffolds. Besides, since the nanofibers in the PCL group and 0% HAP group were the same, the cell morphology of the two groups was very close, the cell spreading shape was relatively uniform and the aspect ratio was close.…”

Section: In Vitromentioning

confidence: 87%

Antibacterial and Osteogenic Dual-Functional Micronano Composite Scaffold Fabricated via Melt Electrowriting and Solution Electrospinning for Bone Tissue Engineering

Lai,

Huang,

Huang

et al. 2024

ACS Appl. Mater. Interfaces

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The utilization of micronano composite scaffolds has been extensively demonstrated to confer the superior advantages in bone repair compared to single nano-or micron-sized scaffolds. Nevertheless, the enhancement of bioactivities within these composite scaffolds remains challenging. In this study, we propose a novel approach to combine melt electrowriting (MEW) and solution electrospinning (SES) techniques for the fabrication of a composite scaffold incorporating hydroxyapatite (HAP), an osteogenic component, and roxithromycin (ROX), an antibacterial active component. Scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR) confirmed the hierarchical architecture of the nanofiber-microgrid within the scaffold, as well as the successful loading of HAP and ROX. The incorporation of HAP enhanced the water absorption capacity of the composite scaffold, thus promoting cell adhesion and proliferation, as well as osteogenic differentiation. Furthermore, ROX resulted in effective antibacterial capability without any observable cytotoxicity. Finally, the scaffolds were applied to a rat calvarial defect model, and the results demonstrated that the 20% HAP group exhibited superior new bone formation without causing adverse reactions. Therefore, our findings present a promising strategy for designing and fabricating bioactive scaffolds for bone regeneration.

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Section: In Vitromentioning

confidence: 87%

Antibacterial and Osteogenic Dual-Functional Micronano Composite Scaffold Fabricated via Melt Electrowriting and Solution Electrospinning for Bone Tissue Engineering

Lai,

Huang,

Huang

et al. 2024

ACS Appl. Mater. Interfaces

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“…51 Li et al developed a bionic porous scaffold with a multicellular structure, which can recruit BMSCs and promote the regeneration and repair of defective bone tissue. 52 In addition, the Masquelet technology has also been proposed as a bone tissue engineering technique. 7 Firstly, PMMA can be used as a sustained-release material loaded antibiotic to effectively control infectious bone defects and create a favorable bone grafting environment for the second stage bone transplantation.…”

Section: Discussionmentioning

confidence: 99%

Fibromodulin facilitates the osteogenic effect of Masquelet's induced membrane by inhibiting the TGF-β/SMAD signaling pathway

Wang,

Zhou,

Zhang

et al. 2024

Biomater. Sci.

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“…In addition to natural polymers, synthetic polymer-based 3D biomaterials can also be used as scaffolds for tissue engineering applications, as well as drug delivery systems, including poly (lactic acid) (PLA), PCL, and PLGA, as shown in figure 15(b). Li et al [116] utilized PLA as the base material, incorporated nHAP, and utilized Mg and CS as active factors. In vitro experiments demonstrated that the scaffold exhibited excellent biocompatibility and could induce efficient osteogenic differentiation.…”

Section: Polymermentioning

confidence: 99%

Advancements in gradient bone scaffolds: enhancing bone regeneration in the treatment of various bone disorders

Zhen,

Shi,

Wang

et al. 2024

Biofabrication

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Bone scaffolds are widely employed for treating various bone disorders, including defects, fractures, and accidents. Gradient bone scaffolds present a promising approach by incorporating gradients in shape, porosity, density, and other properties, mimicking the natural human body structure. This design offers several advantages over traditional scaffolds. A key advantage is the enhanced matching of human tissue properties, facilitating cell adhesion and migration. Furthermore, the gradient structure fosters a smooth transition between scaffold and surrounding tissue, minimizing the risk of inflammation or rejection. Mechanical stability is also improved, providing better support for bone regeneration. Additionally, gradient bone scaffolds can integrate drug delivery systems, enabling controlled release of drugs or growth factors to promote specific cellular activities during the healing process. This comprehensive review examines the design aspects of gradient bone scaffolds, encompassing structure and drug delivery capabilities. By optimizing the scaffold's inherent advantages through gradient design, bone regeneration outcomes can be improved. The insights presented in this article contribute to the academic understanding of gradient bone scaffolds and their applications in bone tissue engineering.

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Multi-scale cellular PLA-based bionic scaffold to promote bone regrowth and repair

Cited by 7 publications

References 44 publications

Antibacterial and Osteogenic Dual-Functional Micronano Composite Scaffold Fabricated via Melt Electrowriting and Solution Electrospinning for Bone Tissue Engineering

Antibacterial and Osteogenic Dual-Functional Micronano Composite Scaffold Fabricated via Melt Electrowriting and Solution Electrospinning for Bone Tissue Engineering

Fibromodulin facilitates the osteogenic effect of Masquelet's induced membrane by inhibiting the TGF-β/SMAD signaling pathway

Advancements in gradient bone scaffolds: enhancing bone regeneration in the treatment of various bone disorders

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