Multi-scale mechanotransduction of the poroelastic signals from osteon to osteocyte in bone tissue

Wu, Xiaogang; Li, Chaoxin; Chen, Kuijun; Sun, Yuqin; Yu, Wei-Lun; Zhang, Meizhen; Wang, Yanqin; Qin, Yi‐Xian; Chen, Weiyi

doi:10.1007/s10409-020-00975-y

Cited by 13 publications

(13 citation statements)

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“…PG refers to the change of pressure per unit length along the direction of fluid flow. It is one of the main driving forces of fluid flow and other effects (FSS, streaming potential and solute transport) in the osteon [4,5,18,19]. Under the axial symmetrical load, the distribution of the PG magnitude in Case 1-Case 6 were quite different from Reference model.…”

Section: Resultsmentioning

confidence: 99%

“…PG refers to the change of pressure per unit length along the direction of fluid flow. This important parameter is often not discussed in previous studies [4,6,19,20].…”

Section: Discussionmentioning

confidence: 95%

“…Due to the periodicity of geometrical configuration, we defined the representative elementary volume (REV) by CUPC. Using poroelasticity theory to describe the fluid flow behavior in osteon was proved to be efficient [4,5,8,19,20].…”

Section: Establishment Of Governing Equation and Finite Element Model Of Osteon Governing Equationmentioning

confidence: 99%

“…However, osteocytes are embedded in mineralized extracellular matrix, and direct experimental research is difficult. In order to observe the mechanotransduction and biomechanical behaviours of osteocytes, researchers tried to overcome this problem by establishing mathematical models of fluid flow in bone matrix [3,4]. Poroelasticity is a well-developed theory for investigating the interaction of fluid and solid phases in bone.…”

Section: Introductionmentioning

confidence: 99%

“…Permeability is an important characteristic affecting interstitial fluid flow in bone. Using numerical simulation to explore the fluid flow induced by mechanical loading, the researchers calculate the values of PP, FV and FSS in bone by poroelastic model [4][5][6][7][8]. However, these models assume that the permeability of bone is isotropic (osteocytes are spherical), which can't accurately reflect the specific microstructure of the bone (such as the shape, direction and density of lacuna-canalicular system.…”

Section: Introductionmentioning

confidence: 99%

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Effects of changes of osteocyte shape on fluid flow and fluid shear stress of loaded bone

Huo

et al. 2021

Preprint

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Background: Load-induced pressure gradients (PG) result in interstitial fluid flow in bone tissue, which is not only provides sufficient nutrient supply and metabolic pathway for the bone cells, but also enables bone cells to accept external mechanical signals. Methods: We calculate the number and distribution of bone canaliculus around the osteocyte based on the varying shape of osteocyte, and then use these calculated parameters and other microstructure data of bone tissue to estimate the anisotropy permeability of the lacunar–canalicular. Finally, according to the calculated parameters, the poroelastic finite element models of the osteon are established, and the influence of the osteocyte shape on the fluid flow properties of osteon under the axial displacement load is analyzed. Two kinds of boundary conditions are considered on the cement line of osteon, elastic restrained (BC1) and displacement confined (BC2). Results: In the range of parameters we studied, the changes of osteocyte shape (Case1-Case6) make the maximum value of PG, pore pressure (PP), fluid velocity (FV) and fluid shear stress (FSS) 33.36%, 67.67%, 8.6% and 26.6% larger than the Reference model in BC1, respectively. And the maximum value of PG, PP, FV and FSS are 65.39%, 67.67%, 8.4% and 29% larger than reference model in BC2. The maximum PG, PP, FV and FSS in BC2 are 96.72%, 95.51%, 97.87% and 97.13% larger than that in BC1, respectively. The permeability of elongated osteocyte model (Case 3, Case 4 and Case 6) have a difference of one magnitude order in X and Y direction. Conclusion: The changes of osteocyte shape has a significant impact on the degrees of anisotropy for fluid flow and porous media of osteon. This model can facilitate better accurately quantifying the fluid flow in lacuna-canalicular system.

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Section: Resultsmentioning

confidence: 99%

“…PG refers to the change of pressure per unit length along the direction of fluid flow. This important parameter is often not discussed in previous studies [4,6,19,20].…”

Section: Discussionmentioning

confidence: 95%