Multi-scale modeling of a wound-healing cell migration assay

Cai, Anna Q.; Landman, Kerry A.; Hughes, Barry D.

doi:10.1016/j.jtbi.2006.10.024

Cited by 185 publications

(255 citation statements)

References 29 publications

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“…Several forms have been proposed in the literature to describe evolution, biogeography, and wound healing by epithelium cells. Here, we consider a model where contact inhibition strength I is used to mildly modify the effective diffusion coefficient of the cells (26):…”

Section: Resultsmentioning

confidence: 99%

Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape

Liu

Sun

Pedersen

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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The metastatic invasion of cancer cells from primary tumors to distant ecological niches, rather than the primary tumors, is the cause of much cancer mortality [Zhang QB, et al. (2010) . We have constructed a microfabricated chip with a three-dimensional topology consisting of lowlands and isolated square highlands (Tepuis), which stand hundreds of microns above the lowlands, in order to assess cancer cell metastatic potential as they invade the highlands. As a test case, the invasive ascents of the Tepui by highly metastatic PC-3 and noninvasive LNCaP prostate cancer cells were used. The vertical ascent by prostate cancer cells from the lowlands to the tops of the Tepui was imaged using confocal microscopy and used as a measure of the relative invasiveness. The less-metastatic cells (LNCaP) never populated all available tops, leaving about 15% of them unoccupied, whereas the more metastatic PC-3 cells occupied all available Tepuis. We argue that this distinct difference in invasiveness is due to contact inhibition.biological physics | oncology | microfabrication

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Section: Resultsmentioning

confidence: 99%

Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape

Liu

Sun

Pedersen

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

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“…where D x and D y are the diffusivities in the orthogonal x and y directions, respectively (Cai et al 2007;Hughes 1995). We note that this standard approach makes the simplifying assumption that the diffusivities are constant and do not change over time (Massey et al 2012).…”

Section: Estimating the Random Motility Ratementioning

confidence: 99%

Experimental and Modelling Investigation of Monolayer Development with Clustering

et al. 2013

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“…• (Gruler and Bültmann, 1984;Friedl et al, 1998;Maini et al, 2004;Cai et al, 2007). Several experimental studies have looked into the chemotactic effect on osteogenic cells migration (Fiedler et al, 2004(Fiedler et al, , 2005(Fiedler et al, , 2006Lee et al, 2006).…”

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confidence: 99%